The Effect of Intradermal Botulinum Toxin on Androgenetic Alopecia and Its Possible Mechanism

    Uri Shon, Myung Kyum Kim, Dong Ho Lee, Hwan Mook Kim, Byung Joo Park
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    TLDR Botulinum toxin injections may help treat hair loss by blocking harmful secretion in hair follicles.
    The study evaluated the efficacy and safety of intradermal injection of botulinum toxin (BTX) in treating androgenetic alopecia (AGA) and its relationship with transforming growth factor-B1 (TGF-B1). The study found that BTX successfully abrogated DHT-induced secretion of TGF-ß1 from dermal papilla cells (DPC) and was effective against AGA by inhibiting TGF-ß1 secretion in the hair bulb, which is thought to suppress follicular keratinocyte growth and changes in the hair cycle. The study suggests that intradermal injection of botulinum toxin could be a possible treatment option for AGA by inhibiting TGF-ß1 secretion from the hair follicles. However, further research and long-term follow-up are required. The study comprised 18 male patients with a mean age of 49.00 ± 6.50.
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