Efficacy of Botulinum Toxin A Injection in the Treatment of Androgenic Alopecia: A Comparative Controlled Study

January 2022 in “ Journal of Cosmetic Dermatology ”

Amany Nassar, Heba Abdel-Aleem, Mai Samir, Fathia M Khattab

botulinum toxin A androgenic alopecia LC hair essence serum trichoscopy irritation headache Botox AGA

Studysummary This study found that for treating androgenetic alopecia, LC hair essence serum injections provided excellent results with fewer side effects compared to botulinum toxin A, which also showed significant efficacy but with higher associated costs and more frequent side effects. Our plain-language summary of this paper — not a Tressless recommendation.

The study "Efficacy of botulinum toxin A injection in the treatment of androgenic alopecia: A Comparative Controlled Study" involved 62 patients with androgenetic alopecia (AGA). The patients were divided into two groups: Group I (31 patients) received 1 ml of LC hair essence serum diluted with 0.5 ml of 0.9% normal saline once weekly for 8 weeks, and Group II (31 patients) were injected with 50 units of botulinum toxin A. The results showed a significant difference in trichoscopy findings between the baseline and the end of the sixth month in the Botox group, and a highly significant difference in the LC group. There was a statistically significant increase in the frequency of side effects (irritation and headache) in Group II compared to Group I. The study concluded that Botox can induce significant results in the treatment of AGA with mild and tolerable side effects but at a high cost, while LC hair serum exhibited excellent results with fewer side effects.

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Research cited in this study

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research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

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research A Pilot Study to Evaluate Effectiveness of Botulinum Toxin in Treatment of Androgenetic Alopecia in Males

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research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

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This article presents a classification system for stages of female-pattern androgenetic alopecia to aid early diagnosis and mentions existing systems for rare male-pattern cases, but reports no new clinical results.