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    Glossary Hand-Foot Syndrome

    causes redness, swelling, and pain on palms and soles

    Hand-Foot Syndrome, also known as Palmar-Plantar Erythrodysesthesia (PPE), is a side effect of certain chemotherapy drugs. It causes redness, swelling, and pain on the palms of the hands and the soles of the feet, and in severe cases, can lead to blistering and peeling of the skin. This condition occurs because the chemotherapy drugs leak out of the capillaries in these areas, leading to inflammation and damage.

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    1. Pathogenesis of Hand-Foot Syndrome induced by PEG-modified liposomal Doxorubicin Human cell · 2013 · 63 citations
    2. High incidence of severe hand–foot syndrome during capecitabine–docetaxel combination chemotherapy Annals of Oncology · 2003 · 14 citations
    3. Hand-Foot and Stump Syndrome to Sorafenib Journal of Clinical Oncology · 2007 · 45 citations
    4. Cutaneous toxicities of cancer therapy 2002 · 114 citations
    5. Pegylated Liposomal Doxorubicin in the Treatment of Breast Cancer Clinical breast cancer · 2003 · 108 citations
    6. Doxil (Caelyx): an exploratory study with pharmacokinetics in patients with hormone-refractory prostate cancer Anti-cancer drugs · 2000 · 81 citations
    7. Clinical development and management of adverse events associated with FGFR inhibitors Cell Reports Medicine · 2023 · 65 citations
    8. Cutaneous Reactions to Chemotherapeutic Agents ˜The œAmerican journal of the medical sciences · 2001 · 53 citations
    9. Advances in the Management of Cutaneous Toxicities of Targeted Therapies Seminars in Oncology · 2012 · 42 citations
    10. Management of adverse events and other practical considerations in patients receiving capecitabine (Xeloda®) European journal of oncology nursing · 2004 · 35 citations
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