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Glossary Hand-Foot Syndrome

causes redness, swelling, and pain on palms and soles

Hand-Foot Syndrome, also known as Palmar-Plantar Erythrodysesthesia (PPE), is a side effect of certain chemotherapy drugs. It causes redness, swelling, and pain on the palms of the hands and the soles of the feet, and in severe cases, can lead to blistering and peeling of the skin. This condition occurs because the chemotherapy drugs leak out of the capillaries in these areas, leading to inflammation and damage.

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Research

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research Pathogenesis of Hand-Foot Syndrome induced by PEG-modified liposomal Doxorubicin

63 citations , February 2013 in “Human cell”

In this study using an animal model, researchers found that PEGL-DOX, unlike DOX, causes Hand-Foot Syndrome due to reactive oxygen species interacting with skin tissue, leading to skin-specific inflammatory responses.

research High incidence of severe hand–foot syndrome during capecitabine–docetaxel combination chemotherapy

14 citations , October 2003 in “Annals of Oncology”

In this study, the researchers observed that the severity of capecitabine-induced hand-foot syndrome in advanced gastric cancer patients was not linked to the IVS14+1G→A mutation in the DPYD gene.

research Hand-Foot and Stump Syndrome to Sorafenib

45 citations , January 2007 in “Journal of Clinical Oncology”

This case report identifies hand-foot and stump syndrome as a potential side effect of sorafenib therapy in a 47-year-old man with a leg amputation.

research Cutaneous toxicities of cancer therapy

114 citations , March 2002 in “Current opinion in oncology/Current opinion in oncology, with cancerlit”

This review discusses various skin side effects from chemotherapy, noting that they are mainly toxic rather than allergic and often include alopecia, which can cause significant distress to patients.

research Pegylated Liposomal Doxorubicin in the Treatment of Breast Cancer

108 citations , December 2003 in “Clinical breast cancer”

The authors concluded that pegylated liposomal doxorubicin may offer comparable efficacy to conventional doxorubicin with reduced toxicity in metastatic breast cancer treatment.

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community If you can give one advice to your younger self then what that would be?

2744 upvotes 2 years ago

Users discussed hair loss treatments, specifically minoxidil and finasteride. They shared personal experiences and advice on starting these treatments early.

community Why not just take the drugs before hair loss?

in Chat 123 upvotes 6 months ago

Finasteride and dutasteride are discussed as preventative treatments for hair loss, with some advocating for early use and others concerned about side effects, especially before full maturity. Many regret not starting these treatments earlier due to their effectiveness in preventing or slowing hair loss.

community My friend is so terrified of balding, he started microdosing estrogen…

in Treatment 1522 upvotes 9 months ago

A person is microdosing estrogen for hair loss after finasteride and dutasteride failed, risking feminizing effects. Alternatives like minoxidil, RU58841, or hair transplants are suggested.

community If you're sitting there wondering, "I'm losing my hair, what do I do?" then read my advice here. I've been fighting the fight for 7 years, with great success. (pictures included)

107 upvotes 13 years ago

Fighting hair loss with "The Big 3" treatments of Propecia, Rogaine and Nizoral shampoo, as well as specific advice on how to use these products. People have shared their long-term success stories and some have discussed the side effects of finasteride. Other suggestions included Lipogaine and Pura D'or Hair Loss Prevention Therapy Shampoo & Conditioner.

community I know this has probably been posted before, and sorry for the language, but thank fucking God we have finasteride, imagine being born 70 years ago, you'd be rubbing rosemary oil, rabbits foot, and herbal shit onto your horseshoe. At least we stand a chance. Thank fuck for finasteride.

135 upvotes 2 weeks ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and dutasteride, with some users expressing gratitude for these modern solutions compared to past remedies. Opinions vary, with some users skeptical about the effectiveness and societal impact of these treatments.

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Hair System Specialist
Michelle Foote
Ipswich, England, United Kingdom

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Michelle Foote