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    Glossary Hand-Foot Syndrome

    causes redness, swelling, and pain on palms and soles

    Hand-Foot Syndrome, also known as Palmar-Plantar Erythrodysesthesia (PPE), is a side effect of certain chemotherapy drugs. It causes redness, swelling, and pain on the palms of the hands and the soles of the feet, and in severe cases, can lead to blistering and peeling of the skin. This condition occurs because the chemotherapy drugs leak out of the capillaries in these areas, leading to inflammation and damage.

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    1. Pathogenesis of Hand-Foot Syndrome induced by PEG-modified liposomal Doxorubicin Human cell · 2013 · 63 citations
    2. High incidence of severe hand–foot syndrome during capecitabine–docetaxel combination chemotherapy Annals of Oncology · 2003 · 14 citations
    3. Hand-Foot and Stump Syndrome to Sorafenib Journal of Clinical Oncology · 2007 · 45 citations
    4. Cutaneous toxicities of cancer therapy 2002 · 114 citations
    5. Pegylated Liposomal Doxorubicin in the Treatment of Breast Cancer Clinical breast cancer · 2003 · 108 citations
    6. Doxil (Caelyx): an exploratory study with pharmacokinetics in patients with hormone-refractory prostate cancer Anti-cancer drugs · 2000 · 81 citations
    7. Clinical development and management of adverse events associated with FGFR inhibitors Cell Reports Medicine · 2023 · 65 citations
    8. Cutaneous Reactions to Chemotherapeutic Agents ˜The œAmerican journal of the medical sciences · 2001 · 53 citations
    9. Advances in the Management of Cutaneous Toxicities of Targeted Therapies Seminars in Oncology · 2012 · 42 citations
    10. Management of adverse events and other practical considerations in patients receiving capecitabine (Xeloda®) European journal of oncology nursing · 2004 · 35 citations
    11. Cutaneous Drug Eruptions Associated with the Use of New Oncological Drugs 2012 · 29 citations
    12. Skin toxicity of anti‐cancer therapy Journal der Deutschen Dermatologischen Gesellschaft · 2008 · 19 citations
    13. The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors Postępy Dermatologii i Alergologii · 2017 · 18 citations
    14. Cutaneous reactions to targeted therapies in children with CNS tumors: A cross‐sectional study Pediatric Blood & Cancer · 2019 · 16 citations
    15. Prophylaxis and Management of Skin Toxicities Breast care · 2019 · 15 citations
    16. Clinical Management of Cutaneous Adverse Events in Patients on Chemotherapy: A National Consensus Statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology 2019 · 12 citations
    17. Patient‐Level Adverse Event Patterns in a Single‐Institution Study of the Multi‐Kinase Inhibitor Sorafenib Clinical and translational science · 2016 · 10 citations
    18. The risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients: a systematic review and meta-analysis Cutaneous and Ocular Toxicology · 2018 · 9 citations
    19. Cutaneous adverse events to systemic antineoplastic therapies: a retrospective study in a public oncologic hospital Anais Brasileiros de Dermatologia · 2021 · 7 citations
    20. Cutaneous toxicities of new targeted cancer therapies: must know for diagnosis, management, and patient-proxy empowerment Annals of palliative medicine · 2019 · 7 citations
    21. Targeted Therapy– and Chemotherapy-Associated Skin Toxicities: Systematic Review and Meta-Analysis Oncology nursing forum · 2020 · 6 citations
    22. Dermatologic adverse events associated with chemotherapy and targeted anticancer therapy Dermatology Review · 2016 · 4 citations
    23. Cutaneous Adverse Events of Targeted Anticancer Therapy: A Review of Common Clinical Manifestations and Management DOAJ (DOAJ: Directory of Open Access Journals) · 2015 · 2 citations
    24. Topoisomerase‐Interacting Agents 2013 · 2 citations
    25. Large-Scale, Multicenter, Prospective Registry Study of Ripretinib in Advanced GIST: A Real-World Study from China Advances in therapy · 2023 · 1 citations
    26. Chemotherapy and Cutaneous Drug Reactions Springer eBooks · 2015 · 1 citations
    27. Skin toxicity induced by chemotherapy or molecular targeted therapy combined with immune checkpoint inhibitors in Asian patients: A literature review by the Japanese Pharmacist-led Oncodermatology Study Team International Journal of Clinical Oncology · 2026
    28. Chemotherapy and the Skin: Understanding Dermatologic Side Effects Cureus · 2026
    29. Comparative Outcomes of Cutaneous Vesicostomy Versus Cystoscopic Valve Ablation in the Initial Management of Posterior Urethral Valves ARC Journal of Urology · 2025
    30. Dermatologic Side Effects of Systemic Targeted Anticancer Therapy Springer eBooks · 2018