Pathogenesis of Hand-Foot Syndrome Induced by PEG-Modified Liposomal Doxorubicin

    February 2013 in “ Human cell
    Noriyuki Yokomichi, Teruaki Nagasawa, Ariella Coler‐Reilly, Hiroyuki Suzuki, Yoshiki Kubota, Ryosuke Yoshioka, Akiko Tozawa, Nao Suzuki, Yoko Yamaguchi
    Image of study
    TLDR PEGL-DOX causes Hand-Foot Syndrome due to skin reactions from prolonged circulation and ROS generation.
    PEGL-DOX was an effective treatment for recurrent ovarian cancer with minimal side effects like cardiotoxicity or hair loss, but it frequently caused Hand-Foot Syndrome (HFS). The study used an animal model to compare DOX and PEGL-DOX, finding that only PEGL-DOX led to HFS due to extravasation from prolonged circulation. The primary cause of skin-specific outbreaks was reactive oxygen species (ROS) generated from interactions between DOX and Cu(II) ions in skin tissue, leading to keratinocyte apoptosis. This apoptosis, detected by the thermoreceptor TRPM2, triggered the release of chemokines and cytokines, causing inflammation. Future research aimed to develop treatments to trap ROS and prevent HFS.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 51 results

      community Discussion on Finasteride and life.

      in Chat  166 upvotes 11 months ago
      Finasteride can aid hair regrowth but may cause side effects like depression and sexual dysfunction. Users discuss experiences with finasteride, minoxidil, and RU58841, highlighting varied responses and the importance of informed treatment choices.

      community Topical finasteride carrier vehicle

      in Finasteride/Dutasteride  1 upvotes 3 weeks ago
      The user is using a topical solution containing 1% finasteride and 5% minoxidil for hair loss, with water, glycerin, and PEG-40 hydrogenated castor oil as carrier agents. They are questioning if these ingredients are effective carriers after using the solution for three months.

      community Possible natural pp405 solution

      in Research/Science  45 upvotes 1 month ago
      Rotenone, a natural plant extract, may promote hair growth by increasing LDH activity and blocking MPC in the scalp, but it carries risks due to its toxicity. The suggested formulation includes Barbasco extract, DMSO, propylene glycol or PEG-400, ethanol, and a carrier oil.

      community Am I crazy to combine oral and topical Finasteride?

      in Finasteride/Dutasteride  5 upvotes 1 week ago
      A 24-year-old male combines topical and oral finasteride with minoxidil to combat hair loss, experiencing heavy shedding but no significant side effects. Other users share their experiences with similar combinations, including using dutasteride and ketoconazole, emphasizing that personalized routines can be effective.

    Similar Research

    5 / 775 results