How Biodegradable Polymers Can Be Effective Drug Delivery Systems for Cannabinoids: Perspectives and Challenges

The document discusses the potential of biodegradable polymers as effective drug delivery systems for cannabinoids, highlighting their ability to enhance bioavailability, stability, and targeted delivery. Key findings include significant improvements in drug solubility and therapeutic efficacy, such as a ~20-fold increase in Cmax and a 14-fold increase in AUC for CBD when encapsulated in PEG-b-PCL nanoparticles. Studies also show promising results in pain management, cancer treatment, and neurological disorders. However, challenges like precise control over drug release rates, biocompatibility, and overcoming biological barriers remain. The review emphasizes the need for further research to optimize these systems for clinical applications.