Treatment Advances for Acne Vulgaris: The Scientific Role of Cannabinoids

The review article "Treatment Advances for Acne Vulgaris: The Scientific Role of Cannabinoids" explores the potential of cannabinoids, particularly cannabidiol (CBD), as a novel treatment for acne vulgaris due to their lipostatic, anti-inflammatory, antiproliferative, and antimicrobial properties. Pre-clinical and clinical studies, including a phase 2 trial with 368 patients, have shown that CBD can modulate sebum production, reduce inflammation, and inhibit bacterial growth, making it a promising alternative to conventional acne treatments. The review emphasizes the need for further research to confirm long-term safety, optimal dosages, and the benefits of other cannabinoids and advanced delivery systems like nanotechnology. Despite promising results, regulatory challenges and the need for clinical validation remain significant hurdles.