Microneedle-Based Technologies for Long-Acting Transdermal Drug Delivery in Wearable Devices

    December 2025 in “ Sensors ”
    Jiaxin Luo, Yinqi Dai, Xin Cheng, Zifeng Wang, Zhigang Zhu
    This review highlights recent advancements in microneedle-based transdermal drug delivery systems, focusing on their potential for long-acting applications in wearable devices. It categorizes microneedles by delivery mechanism and emphasizes the use of biodegradable synthetic and natural polymers, such as PLA, PLGA, PCL, silk fibroin, and chitosan, for sustained drug release. The review also discusses the integration of advanced drug carriers like liposomes and polymeric nanoparticles to enhance drug-loading capacity and prolong release duration. Key challenges for clinical translation include ensuring manufacturing consistency, maintaining sterility, and validating long-term in vivo efficacy and safety.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community I think this is my stop, gentlepeople. So long and thanks for all the data 👋

      in Transgender  2264 upvotes 8 months ago
      A user shared their successful experience with hair regrowth and transitioning from male to female using minoxidil, finasteride, Nutrafol, microneedling, and hormone replacement therapy (HRT). They expressed gratitude for the results and encouraged others to explore treatments that align with their personal goals.

      community The Fear of Oral Minoxidil is Overblown

      in Research/Science  272 upvotes 8 months ago
      Low-dose oral minoxidil is a safe and effective hair loss treatment with fewer side effects than previously feared. Users often prefer it over topical minoxidil for better results, though some experience side effects like increased body hair and cardiovascular issues.

      community only microneedling and supplements

      in Progress Pictures  67 upvotes 7 months ago
      The user used microneedling, zinc, vitamin D3, biotin, magnesium, saw palmetto, pumpkin seed oil, and a DHT-blocker shampoo with biotin for hair loss. They are considering adding minoxidil due to stagnation in progress.

      community My strong recommendation for those shedding hair

      in Treatment  94 upvotes 4 years ago
      A user with aggressive male pattern baldness found that topical melatonin significantly reduced their hair shedding to 1 or 2 hairs per day and noticed some thickening of side hair. They tried many treatments like finasteride and minoxidil with little success, but topical melatonin showed immediate results in reducing hair loss.

    Similar Research

    5 / 955 results