TLDR Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.
The document discussed the intricate relationship between cell polarity signaling and tissue mechanics, emphasizing how polarity proteins and mechanical forces coordinated to influence cell fate and tissue organization. It highlighted the roles of various polarity protein complexes in establishing cellular asymmetry and their interactions with the cytoskeleton to sense and transmit mechanical forces. The study explored how spindle orientation, influenced by both intrinsic and extrinsic cues, affected cell division and differentiation in different tissues. It underscored the importance of mechanical properties and polarity signaling in tissue morphogenesis, homeostasis, and their implications in cancer progression and wound healing.
5 citations,
May 2021 in “EMBO journal” Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.
26 citations,
July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The protein Par3 is crucial for healthy skin, affecting the skin barrier, cell differentiation, and stem cell maintenance.
242 citations,
February 2016 in “Science” Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
January 2018 in “Stem cell biology and regenerative medicine” The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.
57 citations,
March 2018 in “International Journal of Molecular Sciences” The extracellular matrix is crucial for controlling skin stem cell behavior and health.
1039 citations,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
January 2018 in “Stem cell biology and regenerative medicine” The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
150 citations,
December 2012 in “EMBO Reports” Stem cell self-renewal is complex and needs more research for full understanding.
