TLDR Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.
The document discussed the intricate relationship between cell polarity signaling and tissue mechanics, emphasizing how polarity proteins and mechanical forces coordinated to influence cell fate and tissue organization. It highlighted the roles of various polarity protein complexes in establishing cellular asymmetry and their interactions with the cytoskeleton to sense and transmit mechanical forces. The study explored how spindle orientation, influenced by both intrinsic and extrinsic cues, affected cell division and differentiation in different tissues. It underscored the importance of mechanical properties and polarity signaling in tissue morphogenesis, homeostasis, and their implications in cancer progression and wound healing.
5 citations
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May 2021 in “EMBO journal” Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.
38 citations
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July 2019 in “Nature Communications” Par3 protein is essential for skin cell balance and stability.
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March 2017 in “Nature Communications” Stem cells help heal wounds by rapidly dividing and migrating to the wound edge.
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July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The protein Par3 is crucial for healthy skin, affecting the skin barrier, cell differentiation, and stem cell maintenance.
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February 2016 in “Science” Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
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March 2018 in “International Journal of Molecular Sciences” The extracellular matrix is crucial for controlling skin stem cell behavior and health.
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November 2016 in “EMBO Reports” Disruptions in mammary stem cell division can lead to cancer, but targeting these processes might help treat breast cancer.
