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    Essential Role of Polarity Protein Par3 for Epidermal Homeostasis Through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

    July 2016 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Noelle Ali, Martim Gomes, Ronja Bauer … Sandra Iden
    Studysummary In this study, loss of epidermal Par3 in mice disrupted the skin barrier and affected cell differentiation and stem cell maintenance, highlighting its role in epidermal homeostasis.
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    Research cited in this study 10

    1. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    2. Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence Journal of Investigative Dermatology · 2015
    3. Plasticity of Epithelial Stem Cells in Tissue Regeneration Science · 2014
    4. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013
    5. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    6. Development and Homeostasis of the Sebaceous Gland Seminars in Cell & Developmental Biology · 2012
    7. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    8. TCF/Lef1 Activity Controls Establishment of Diverse Stem and Progenitor Cell Compartments in Mouse Epidermis The EMBO Journal · 2011
    9. Epidermal Stem Cell Diversity and Quiescence EMBO molecular medicine · 2009
    10. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009