Targeting the Stem Cell Niche: Role of Collagen XVII in Skin Aging and Wound Repair

January 2022 in “ Theranostics ”

Yangdan Liu, Chiakang Ho, Dongsheng Wen, Jian Sun, Haojie Lu, Ya Gao, Qingfeng Li, Yifan Zhang

TLDR Collagen XVII is important for skin aging and wound healing.

This review highlights the crucial role of Collagen XVII (COL17) in maintaining stem cell niches within the skin epidermis and hair follicles, which are essential for skin homeostasis. COL17, a transmembrane protein in hemidesmosomes, facilitates interactions between stem cells and their microenvironment, influencing their self-renewal abilities. The study emphasizes that while stem cell self-renewal decreases with skin aging, it increases during wound repair. Understanding COL17's function in these processes is key to developing strategies for combating skin aging and enhancing wound healing.

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Research cited in this study

8 / 8 results

research Wnt/β-Catenin Signaling Stabilizes Hemidesmosomes in Keratinocytes

5 citations, November 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Wnt/β-catenin signaling is important for keeping skin cell attachment structures stable.

research Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis

25 citations, April 2021 in “The EMBO Journal”

Hair follicle stem cells help maintain skin health and could improve skin replacement therapies.

Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation

research Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation

11 citations, June 2019 in “Tissue & Cell”

Hair stem cells produce a protein called COL17A1 that plays a key role in their development and is linked to hair thinning and baldness.

research Stem Cell Dynamics, Migration, and Plasticity During Wound Healing

211 citations, November 2018 in “Nature Cell Biology”

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

Essential Role of Polarity Protein Par3 for Epidermal Homeostasis Through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

research Essential Role of Polarity Protein Par3 for Epidermal Homeostasis Through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

26 citations, July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The protein Par3 is crucial for healthy skin, affecting the skin barrier, cell differentiation, and stem cell maintenance.

research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

242 citations, February 2016 in “Science”

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

research Advances in Skin Grafting and Treatment of Cutaneous Wounds

518 citations, November 2014 in “Science”

Skin grafting and wound treatment have improved, but we need more research to better understand wound healing and create more effective treatments.

research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations, August 2014 in “Nature Medicine”

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

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Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate

research Stem Cells and Their Niches

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The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.

Targeting the Stem Cell Niche: Role of Collagen XVII in Skin Aging and Wound Repair

Research cited in this study

research Wnt/β-Catenin Signaling Stabilizes Hemidesmosomes in Keratinocytes

research Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis

research Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation

research Stem Cell Dynamics, Migration, and Plasticity During Wound Healing

research Essential Role of Polarity Protein Par3 for Epidermal Homeostasis Through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

research Advances in Skin Grafting and Treatment of Cutaneous Wounds

research Emerging Interactions Between Skin Stem Cells and Their Niches

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