Targeting the Stem Cell Niche: Role of Collagen XVII in Skin Aging and Wound Repair

    January 2022 in “ Theranostics ”
    Yangdan Liu, Chiakang Ho, Dongsheng Wen … Yifan Zhang
    Studysummary This review discusses the role of collagen XVII in maintaining stem cell niches and its impact on skin aging and wound repair, without reporting new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 12

    1. Wnt/β-Catenin Signaling Stabilizes Hemidesmosomes in Keratinocytes ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2021
    2. Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis The EMBO Journal · 2021
    3. Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation Tissue & Cell · 2019
    4. Stem Cell Dynamics, Migration, and Plasticity During Wound Healing Nature Cell Biology · 2018
    5. Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis eLife · 2017
    6. Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis Nature Communications · 2017
    7. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis Through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2016
    8. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    9. Advances in Skin Grafting and Treatment of Cutaneous Wounds Science · 2014
    10. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    11. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    12. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005