Targeting the Stem Cell Niche: Role of Collagen XVII in Skin Aging and Wound Repair
January 2022
in “
Theranostics
”
Collagen XVII COL17 stem cell niche skin epidermis hair follicles skin homeostasis transmembrane protein hemidesmosomes stem cell self-renewal skin aging wound repair Collagen 17 stem cell environment skin surface hair roots skin balance cell membrane protein cell junctions stem cell renewal wound healing
TLDR Collagen XVII is important for skin aging and wound healing.
This review highlights the crucial role of Collagen XVII (COL17) in maintaining stem cell niches within the skin epidermis and hair follicles, which are essential for skin homeostasis. COL17, a transmembrane protein in hemidesmosomes, facilitates interactions between stem cells and their microenvironment, influencing their self-renewal abilities. The study emphasizes that while stem cell self-renewal decreases with skin aging, it increases during wound repair. Understanding COL17's function in these processes is key to developing strategies for combating skin aging and enhancing wound healing.
