Recombinant Humanized Collagen Combined With Nicotinamide Increases Expression of Rat Basement Membrane Proteins and Promotes Hair Growth

June 2025 in “ Frontiers in Bioengineering and Biotechnology ”

Y.F. Zhou, Bo‐Yu Chen, Shijia Ye, Haoyu Sun, Shuyue Wang, Xiaozhen Diao, Wenhui Wu

recombinant humanized collagen nicotinamide collagen type III collagen type XVII collagen type XXI laminin integrin VEGF β-integrin hair follicle density minoxidil androgenic alopecia vitamin B3 Rogaine

From the encyclopedia

nicotinamide →

Vascular Endothelial Growth Factor →

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary In this study, the researchers observed that a recombinant human collagen complex with nicotinamide promoted hair growth in rat models, increased hair follicle stem cell survival, and enhanced key protein expression, suggesting potential benefits for hair health and loss prevention.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study explores the effects of a recombinant humanized collagen (RHC) complex combined with nicotinamide on hair growth in 35 Wistar rats. The RHC complex, containing types III, XVII, and XXI collagen, was applied to rat skin, resulting in increased expression of basement membrane proteins like laminin and integrin, and improved hair growth compared to controls. Nicotinamide enhanced cell viability, particularly at higher RHC concentrations, indicating a synergistic effect. The RHC complex also upregulated proteins crucial for hair growth, such as VEGF and β-integrin, and increased hair follicle density, with effects comparable to 5% minoxidil. The optimal concentration for hair growth was 0.1 mg/mL. These findings suggest that the RHC complex with nicotinamide could be a promising treatment for promoting hair growth and improving hair health, offering a potential alternative for treating androgenic alopecia.

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