Recombinant Humanized Collagen Combined With Nicotinamide Increases Expression of Rat Basement Membrane Proteins and Promotes Hair Growth

    June 2025 in “ Frontiers in Bioengineering and Biotechnology ”
    Y.F. Zhou, Bo‐Yu Chen, Shijia Ye … Wenhui Wu
    Studysummary In this study, the researchers observed that a recombinant human collagen complex with nicotinamide promoted hair growth in rat models, increased hair follicle stem cell survival, and enhanced key protein expression, suggesting potential benefits for hair health and loss prevention.
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    15. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009
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