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Glossary Collagen Type VII

protein crucial for anchoring skin layers together

Collagen Type VII is a specific type of collagen protein that plays a crucial role in anchoring the outer layer of the skin (epidermis) to the underlying layer (dermis). It forms structures known as anchoring fibrils, which are essential for maintaining skin integrity and preventing blistering. Defects in Collagen Type VII can lead to a genetic condition called dystrophic epidermolysis bullosa, characterized by fragile skin that easily blisters and tears.

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Research

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Effects of Collagen Type XVII Alpha 1 on Epidermal Stem Cells in Aging Skin and the MicroRNA Intervention Mechanism

research [Effects of collagen type ⅩⅦ α1 on epidermal stem cells in aging skin and the microRNA intervention mechanism].

September 2022 in “PubMed”

This study found that decreased COL17α1 expression in aging mouse skin is associated with reduced proliferation of epidermal stem cells and may contribute to thinner epidermis and slower wound healing.

research Type XVII collagen coordinates proliferation in the interfollicular epidermis

124 citations , July 2017 in “eLife”

This study found that COL17 deficiency in neonatal mice causes abnormal skin cell proliferation due to disrupted Wnt signaling, while replenishing or overexpressing COL17 can reverse this effect in both neonatal and aged skin.

research Recombinant Type XVII Collagen Promotes Hair Growth by Activating the Wnt/β-Catenin and SHH/GLI Signaling Pathways

July 2025 in “Cosmetics”

This study found that recombinant human type XVII collagen (rhCOL17A1) promotes hair growth by activating the Wnt/β-catenin and SHH/GLI signaling pathways and increasing type XVII collagen expression, with significant effects observed in both cell and mouse models.

research Identification of a human type XVII collagen fragment with high capacity for maintaining skin health

June 2024 in “Synthetic and systems biotechnology”

In this study, researchers identified a collagen fragment, sample-1707, expressed in E. coli, which forms nanofibers and promotes blood clotting, osteoblast differentiation, and skin cell regeneration, making it a promising biomaterial for skin care, with a large-scale production yield of 600 mg/L.

research Long-Term Survival of Type XVII Collagen Revertant Cells in an Animal Model of Revertant Cell Therapy

27 citations , July 2013 in “Journal of Investigative Dermatology”

Revertant cell therapy shows promise for treating type XVII collagen deficiency, but better cell selection methods are needed.

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community Age-linked hair loss caused by disappearing collagen, researchers say

62 upvotes 6 years ago

Age-linked hair loss is linked to disappearing collagen. Treatments discussed include minoxidil, finasteride, RU58841, tretinoin, microneedling, and collagen supplements.

community Short Peptides for Hair Loss: anyone tried any of these?

14 upvotes 5 months ago

Various peptides are discussed for treating male pattern baldness, with some available for topical use like GHK-Cu and Ac-KGHK, while others remain in research stages. Users are interested in experiences and sourcing these treatments.

community Collagen/Vitamins/Supplements and skin-care routine while on Minoxidil?

27 upvotes 5 years ago

Minoxidil users discuss skin-care routines to counteract side effects like dark circles and dull skin. Recommendations include vitamin C, potassium, collagen, retinol, nizoral shampoo, and emu oil.

community 5 months on Fin 1 mg + biotin collagen daily supplement I think this is progress but idk and pls help me get more

5 upvotes 6 months ago

The user has been using 1mg finasteride and biotin-collagen supplements for 5 months, noticing some progress in hair regrowth. They also use various oils and shampoos, plan to start oral minoxidil, and seek advice on improving their hair care routine.

community Anybody else notice improved skin/collagen on Dutasteride

6 upvotes 3 years ago

User switched from finasteride to combination dutasteride and finasteride for hair density improvement. They noticed less hair shedding and more youthful skin, with a reply suggesting less DHT could increase elastin in skin.

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