Search

for
Search:

GlossaryDystrophic Epidermolysis Bullosa

rare genetic disorder causing fragile, blistering skin from minor trauma

Dystrophic Epidermolysis Bullosa (DEB) is a rare genetic disorder characterized by extremely fragile skin that blisters and tears from minor friction or trauma. This condition is caused by mutations in the COL7A1 gene, which affects the production of type VII collagen, a protein essential for anchoring the layers of skin together.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 1000+ results

research Availability of mRNA from Peripheral Blood Mononuclear Cells for Mutational Analysis in Dystrophic Epidermolysis Bullosa

November 2022 in “Journal of Investigative Dermatology”

Scientists developed a new way to study mutations in a skin condition using blood cells, which may help diagnose and treat the disease.

research Dominant Dystrophic Epidermolysis Bullosa: Seven Familial Cases

February 2009 in “Journal of The American Academy of Dermatology”

The document concludes that detailed clinical descriptions of seven family cases help understand dominant dystrophic epidermolysis bullosa's symptoms and inheritance.

research Phase I/IIa Clinical Trial for Recessive Dystrophic Epidermolysis Bullosa Using Genetically Corrected Autologous Keratinocytes

5 citations, April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

The gene therapy showed significant wound healing and was safe for treating severe RDEB.

research Defining Chronic Wound Types in Recessive Dystrophic Epidermolysis Bullosa Patients for Clinical Outcome Assessment

2 citations, April 2018 in “Journal of Investigative Dermatology”

The conclusion is that differentiating wound types in RDEB patients is important for clinical trials and understanding the disease.

research CRISPR/Cas9-Based Targeted Genome Editing for Correction of Recessive Dystrophic Epidermolysis Bullosa Using iPS Cells

1 citations, September 2019 in “Journal of Investigative Dermatology”

The research showed that CRISPR/Cas9 can fix mutations causing a skin disease in stem cells, which then improved skin grafts in mice, but more work on safety and efficiency is needed.

View more "dystrophic epidermolysis bullosa" in research →

Community Join

5 / 15 results

community Is it possible to create an estrogen mesotherapy/topical that doesn't go systemic?

in Research/Science 6 upvotes 1 month ago

The conversation discusses the potential of using topical estrogen treatments for hair loss without systemic absorption, highlighting challenges and possible solutions like using estriol. It also mentions other treatments like topical finasteride, microneedling, and scalp massage, while noting the limitations and side effects of current options.

community Losing ground on dut, daily for 5 months after fin and min for a year.

in Finasteride/Dutasteride 91 upvotes 4 weeks ago

The user experienced increased hair thinning after switching from finasteride and minoxidil to dutasteride, despite some users suggesting it might be a temporary shedding phase. The user is considering using RU58841 but is unsure about its safety.

community Hairloss is mentally exhausting

in Chat 25 upvotes 4 years ago

The conversation is about the mental toll of hair loss and seeking alternatives to finasteride. Suggestions include using minoxidil, considering pumpkin seed oil, and possibly seeking counseling for body dysmorphic disorder.

community 5MG finasteride everyday June 1st 2024 - October 7th 2024

in Progress Pictures 182 upvotes 2 months ago

The user has been using 1.25 mg of finasteride daily since June 2024 to promote hair regrowth and thickness, considering switching to dutasteride if results are unsatisfactory. They are hesitant to add minoxidil due to cost and potential side effects but have seen some progress with finasteride alone.

community 5.5 months on oral min questions. Please help😭

in Treatment 11 upvotes 3 months ago

The user has been on finasteride for over a year and switched from topical to oral minoxidil five months ago, but is unsure if the current shedding and small hairs are signs of improvement or worsening. They are seeking advice on whether to wait longer or switch treatments.

View more "dystrophic epidermolysis bullosa" in community →