Chitosan-Based Scaffolds Incorporated with Silver Nanoparticles for the Treatment of Infected Wounds

The document reviews the development and evaluation of chitosan-based scaffolds incorporated with silver nanoparticles (AgNPs) for treating infected wounds. These scaffolds, including sponges, nanofibers, hydrogels, cryogels, films, membranes, foams, and wafers, exhibit superior antibacterial properties and promote faster wound healing. In vitro and in vivo studies show that these materials are effective against common pathogens like E. coli and S. aureus, enhance cell viability, and accelerate wound closure. The incorporation of AgNPs significantly improves the antimicrobial efficacy and overall performance of the dressings, making them promising candidates for advanced wound care applications. However, further research is needed to fully understand their mechanisms and ensure safety in clinical settings.