Homogeneous Silver Nanoparticle Loaded Polydopamine/Polyethyleneimine-Coated Bacterial Cellulose Nanofibers for Wound Dressing

    July 2023 in “ International journal of biological macromolecules ”
    Le Ma, Wenwen Jiang, Xiaowei Xun, Mingzhuo Liu, Xiang Han, Jiale Xie, M. Wang, Quanchao Zhang, Zhaoxiang Peng, Haiyong Ao
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    Studysummary This research observed that a silver nanoparticle-loaded polydopamine/polyethyleneimine-coated bacterial cellulose dressing effectively inhibited S. aureus infections, reduced inflammation, and promoted wound healing compared with untreated cellulose, demonstrating its potential for treating infected wounds. Our plain-language summary of this paper — not a Tressless recommendation.
    The research paper discusses the development of a homogeneous silver nanoparticle (AgNP)-loaded polydopamine/polyethyleneimine (PDA/PEI) coated bacterial cellulose (BC) antibacterial dressing. The BC dressing, due to its inherent properties like 3D nanonetwork structure, gas permeability, water absorbency, and biocompatibility, is an ideal candidate for dressing materials. However, it lacks intrinsic bactericidal performance. To overcome this, the researchers loaded it with antimicrobial agents. The PDA/PEI coating, approximately 4 nm thick, was uniformly attached to the BC fibers, improving its mechanical properties and stability in strongly acidic and alkaline environments. The dressing also demonstrated excellent antibacterial activities and acceptable cytocompatibility, making it suitable for treating infected wounds.
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