Advances in Chitosan-Based Nanoparticles for Drug Delivery

    Veronika Mikušová, Peter Mikuš
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    TLDR Chitosan, a natural substance, can be used to create tiny particles that effectively deliver various types of drugs, but more work is needed to improve stability and control of drug release.
    The document "Advances in Chitosan-Based Nanoparticles for Drug Delivery" discusses the potential of chitosan, a biocompatible and biodegradable polysaccharide, in creating nanoparticles for drug delivery. These nanoparticles can transport a variety of drugs, including anticancer drugs, antibiotics, and genes. The effectiveness of these particles is influenced by factors such as their cross-linking, morphology, size, density, and the drug's physicochemical properties. Various modifications to chitosan can enhance its drug delivery capabilities, including acylated chitosan, which improves matrix stability and promotes nanoparticle self-assembly. The document also highlights the use of chitosan-based nanoparticles in various medical applications, including hair and skin treatments, oral and ocular drug delivery, and targeted drug delivery for diseases like Parkinson’s and Huntington’s. However, further research is needed to address challenges such as stability, drug loading capacity, and controlled release properties.
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