Encapsulation of Curcumin in Polystyrene-Based Nanoparticles: Drug Loading Capacity and Cytotoxicity

    April 2021 in “ ACS omega ”
    Maria Zatorska-Płachta, Grzegorz Łazarski, Urszula Maziarz, Aleksander Foryś, Barbara Trzebicka, Dawid Wnuk, Karolina Chołuj, Anna Karewicz, Marta Michalik, D. Jamroz, Mariusz Kępczyński
    TLDR Curcumin can be effectively loaded into polystyrene nanoparticles, which are safe for human cells and more biocompatible with curcumin inside.
    The study investigated the encapsulation of curcumin in polystyrene-based nanoparticles (PS–PAA NPs), focusing on drug loading capacity and cytotoxicity. The nanoparticles achieved a drug loading capacity of up to 11 wt % and showed minimal impact on particle size. Cytotoxicity tests indicated that curcumin-loaded nanoparticles were less toxic to healthy cells compared to free curcumin, suggesting a safer therapeutic application. The research concluded that encapsulating curcumin during nanoparticle formation was more effective than post-formation, supporting the potential of PS–PAA NPs as a promising drug delivery system for curcumin.
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