Alopecia Management Potential of Rosemary-Based Nanoemulgel Loaded with Metformin: Approach Combining Active Essential Oil and Repurposed Drug

    January 2025 in “ International Journal of Nanomedicine ”
    Kawthar K. Abla, Mariam K. Alamoudi, Gamal A. Soliman … Mohammed M. Mehanna
    Studysummary In this study, a metformin-loaded rosemary-based nanoemulgel was found to significantly enhance hair follicle growth in rats, suggesting its potential as a new treatment for androgenetic alopecia due to its promising physicochemical properties and controlled drug release.
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    Research cited in this study 10

    1. Microsponges-Mediated Targeted Topical Delivery of Rosemary Oil for Hair Growth Promotion: Optimization and In-Vivo Studies Pharmaceutical Development and Technology · 2024
    2. Nanotechnology-Based Techniques for Hair Follicle Regeneration Biomaterials · 2023
    3. Rosmarinus Officinalis Essential Oil Increases Hair Length and Follicle Diameter of Ultraviolet B-Exposed Mice Through VEGF The Indonesian Biomedical Journal · 2023
    4. Exploiting Recent Trends in the Treatment of Androgenic Alopecia Through Topical Nanocarriers of Minoxidil Aaps Pharmscitech · 2022
    5. Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled In Vitro Skin Pharmacology and Physiology · 2021
    6. Microneedles Mediated Bioinspired Lipid Nanocarriers for Targeted Treatment of Alopecia Journal of Controlled Release · 2020
    7. Exploring the Potential of Minoxidil Tretinoin Liposomal-Based Hydrogel for Topical Delivery in the Treatment of Androgenic Alopecia Cutaneous and Ocular Toxicology · 2019
    8. Promotion of Hair Growth by Rosmarinus Officinalis Leaf Extract Phytotherapy Research · 2012
    9. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    10. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002