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    Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled In Vitro

    December 2021 in “ Skin Pharmacology and Physiology
    Chao Sun, Shuang-Hai Hu, Bingqi Dong … Tiechi Lei
    Studysummary In this study, metformin promoted hair follicle regeneration in vitro by enhancing the hair inductive capability of dermal cells, warranting further exploration for pattern hair loss treatment.
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    Research cited in this study 12

    1. Measuring Patient Quality of Life Following Treatment for Alopecia Patient Preference and Adherence · 2021
    2. Follicular Unit Excision: A Hair Transplant Technique Facial Plastic Surgery Clinics of North America · 2020
    3. Hair Regrowth in Two Patients with Recalcitrant Central Centrifugal Cicatricial Alopecia After Use of Topical Metformin JAAD Case Reports · 2020
    4. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    5. Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms International Journal of Molecular Sciences · 2018
    6. Baicalin Increases Hair Follicle Development by Enhancing Canonical Wnt/β-Catenin Signaling and Activating Dermal Papilla Cells in Mice International Journal of Molecular Medicine · 2018
    7. Methods for the Isolation and 3D Culture of Dermal Papilla Cells from Human Hair Follicles Experimental Dermatology · 2017
    8. Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid Stem cells international · 2017
    9. CD133-Positive Dermal Papilla-Derived Wnt Ligands Regulate Postnatal Hair Growth Biochemical Journal · 2016
    10. Comparison of Clinical and Metabolic Effects of Metformin and Pioglitazone in Polycystic Ovary Syndrome Indian journal of endocrinology and metabolism · 2016
    11. Evaluation of Efficacy and Safety of Finasteride 1 mg in 3177 Japanese Men with Androgenetic Alopecia Journal of Dermatology · 2011
    12. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005

    Related research 6

    1. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
    2. Characterization of Hair Follicle Development in Engineered Skin Substitutes PLOS ONE · 2013
    3. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    4. Dermal Papilla Cells Induce Keratinocyte Tubulogenesis in Culture Histochemistry and cell biology · 2010
    5. Hair Follicle Regeneration Using Grafted Rodent and Human Cells Journal of Investigative Dermatology · 2007
    6. Dermal Papilla-Induced Hair Differentiation of Adult Epithelial Stem Cells from Human Skin Physiological Genomics · 2004