Exploring the Potential of Minoxidil Tretinoin Liposomal-Based Hydrogel for Topical Delivery in the Treatment of Androgenic Alopecia

January 2020 in “ Cutaneous and Ocular Toxicology ”

Pratiksha Kochar, Kritika Nayak, Shreya Thakkar, Suryanarayan Polaka, Dignesh Khunt, Manju Misra

minoxidil tretinoin liposomal hydrogel androgenic alopecia topical delivery hair follicles permeation skin Rogaine Retin-A

TLDR Minoxidil tretinoin liposomal based hydrogel shows promise for effective treatment of hair loss by delivering both drugs at the same time.

In 2020, a study was conducted to investigate the potential of a minoxidil tretinoin liposomal based hydrogel for topical treatment of androgenic alopecia. The liposomal hydrogel system was found to be successful in simultaneously delivering minoxidil and tretinoin, overcoming the limitations of existing formulations. The liposomes were stable, homogeneous, and capable of holding both drugs. The hydrogel enhanced the permeation of drugs through the skin and was non-irritant. An ex vivo permeation study showed that about 28.76% of minoxidil permeated through rat skin from the liposomal hydrogel after 6 hours. The formulation reached the desired site of action in the hair follicles. The study concluded that the developed system showed potential for effective and simultaneous delivery of both drugs.

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19 / 19 results

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1 / 1 results

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Exploring the Potential of Minoxidil Tretinoin Liposomal-Based Hydrogel for Topical Delivery in the Treatment of Androgenic Alopecia

Cited in this study

research Efficacy of Off-Label Topical Treatments for the Management of Androgenetic Alopecia: A Review

research Alopecia and Techniques in Hair Restoration: An Overview for the Cosmetic Surgeon

research The Medical and Psychosocial Associations of Alopecia: Recognizing Hair Loss as More Than a Cosmetic Concern

research Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery

research Nanotechnology Advances for Hair Loss

research Alginate-Based Hydrogel Containing Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex for Topical Alopecia Treatment

research Review of Quality of Life Studies in Women with Alopecia

research Minoxidil Promotes Hair Growth Through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells

research Androgenetic Alopecia: Drug Safety and Therapeutic Strategies

research Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version

research Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carriers

research Self-Assembled Polymeric Nanocarriers for the Targeted Delivery of Retinoic Acid to the Hair Follicle

research Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carrier Gel for Effective Treatment of Alopecia

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research Liposomes And Niosomes As Potential Carriers For Dermal Delivery Of Minoxidil

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