Systemic Therapies for Scarring and Non-Scarring Alopecia

The document reviewed systemic therapies for scarring and non-scarring alopecia, highlighting treatments such as sulfasalazine, hydroxychloroquine, simvastatin/ezetimibe, and JAK inhibitors. Sulfasalazine showed promise for alopecia areata, while hydroxychloroquine was ineffective for alopecia totalis. Simvastatin/ezetimibe had potential for hair growth in alopecia areata patients. JAK inhibitors, including tofacitinib and ruxolitinib, were effective in inducing hair regrowth in moderate-to-severe alopecia areata, with studies involving up to 90 patients. Other treatments like abatacept and IL-12/IL-23p40 cytokine antagonism also showed potential in reversing extensive alopecia areata.