TLDR Accurate diagnosis of APL is crucial to avoid unnecessary treatments.
Atrichia with papular lesions (APL) is a rare autosomal recessive disorder characterized by irreversible alopecia and keratin cysts, caused by mutations in the Zinc finger domain of the human hairless gene on chromosome 8p12. An 11-year-old male presented with extensive alopecia starting at six months of age and keratotic papules on the face and trunk. Biopsies confirmed the presence of mid-dermal keratin cysts and few vellus follicles without terminal hairs. Accurate diagnosis of APL is crucial to avoid misdiagnosis as alopecia universalis and unnecessary steroid treatments. Vitamin D-dependent rickets, which has a similar clinical presentation, was ruled out.
July 2021 in “Indian journal of dermatopathology and diagnostic dermatology” Trichoscopy is a reliable method for diagnosing hair and scalp disorders quickly and non-invasively.
4 citations
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January 2020 in “Dermatology Online Journal” Congenital atrichia with papular lesions causes permanent hair loss and skin bumps due to a gene mutation.
109 citations
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May 2011 in “Dermatologic Therapy” Alopecia areata is a type of hair loss that can lead to complete baldness, often associated with other autoimmune conditions, and half of the cases may see hair return within a year.
8 citations
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January 2011 in “International journal of trichology” Accurate diagnosis of APL is crucial to avoid unnecessary treatments.
14 citations
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January 2011 in “International Journal of Trichology” Some people with severe, long-lasting baldness responded well to a specific combination treatment.
129 citations
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June 1999 in “Archives of Dermatology” African Americans have less hair density than whites.
