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GlossaryAtrichia with Papular Lesions (APL)

rare genetic condition causing hair loss and skin bumps

Atrichia with Papular Lesions (APL) is a rare genetic condition characterized by the complete absence of hair (atrichia) shortly after birth, followed by the development of small, firm bumps on the skin (papular lesions). This condition is caused by mutations in the HR gene, which is crucial for hair follicle development and cycling.

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research Outcomes of Tissue Expander Application for Scalp Reconstruction in Extensive Aplasia Cutis Congenita

4 citations , November 2015 in “Aesthetic Plastic Surgery”

Using tissue expanders for scalp reconstruction in patients with extensive Aplasia Cutis Congenita is effective and has minimal complications.

research Aplasia Cutis Congenita on Lumbosacral Area

3 citations , January 2014 in “Indian dermatology online journal”

A newborn girl has a rare skin condition with two ulcers on her buttock that are healing on their own.

research Two Cases of Aplasia Cutis Congenita With Hair Collar Signs and Macrophage Hyperplasia

2 citations , June 2019 in “The Journal of Dermatology”

Two cases showed skin abnormalities without bone or neural defects.

The Use of Human Dermal Papillae Conditioned Medium (HDPCM) on Aplasia Cutis Congenita in Lower Extremity Due to Intrauterine Varicella Infection

research The Use of Human Dermal Papillae Conditioned Medium (HDPCM) on Aplasia Cutis Congenita in Lower Extremity Due to Intrauterine Varicella Infection

1 citations , March 2019 in “KnE life sciences”

HDPCM treatment healed a baby's congenital skin defect caused by varicella infection.

research Clinical Applications in Humans of Platelet-Rich Plasma: Integrative Review

November 2025 in “Contribuciones a las Ciencias Sociales”

PRP is a safe and versatile treatment option, but more standardized clinical trials are needed to confirm its effectiveness.

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community Another transplant or SMP? (Not balding)

in Transplants 23 upvotes 2 months ago

The user is considering another hair transplant or scalp micropigmentation (SMP) for a congenital bald spot, but previous transplants were less effective due to scar tissue. Suggestions include using hair fibers, changing hairstyles, or doing nothing, as the spot is not very noticeable.

community Mixed Minoxidil 2% in the morning, and 5% minoxidil before bed?

in Minoxidil 2 upvotes 2 years ago

A user discusses using a mixed solution with minoxidil 2%, hydrocortisone butyrate, and estrone in the morning, and considering adding 5% minoxidil at night. They also use Restax softgel but avoid finasteride.

community Alguien más le pasa esto por el minoxidil?

in Minoxidil 1 upvotes 6 months ago

A 20-year-old male experienced mental fog after resuming topical minoxidil for hair loss, questioning if it's due to interactions with antidepressants. Suggestions included trying a lower concentration of minoxidil or alternatives like copper peptides.

community Progreso de 3 meses usando minoxidil topico

in Progress Pictures 4 upvotes 7 months ago

The user started using topical minoxidil 5% and ketoconazole shampoo for hair loss, noticing minimal progress after three months, with fine hairs appearing. They experienced a setback when reducing the application to once a day but resumed twice daily applications.

community Advice on routine before potentially starting fin (caffeine shampoo etc)

in Research/Science 1 upvotes 9 months ago

A user is considering hair loss treatments like caffeine shampoo, rosemary oil, pumpkin seed supplements, and microneedling, but is unsure if these are effective compared to finasteride. Another user suggests trying finasteride or dutasteride, sharing regret for not starting earlier.

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