Two Cases of Aplasia Cutis Congenita With Hair Collar Signs and Macrophage Hyperplasia

    June 2019 in “ The Journal of Dermatology ”
    Eriko Takayama, Atsuko Harada, Yoshihiro Ikura, Hidenobu Seto
    TLDR Two cases showed skin abnormalities without bone or neural defects.
    The document reported two cases of aplasia cutis congenita with hair collar signs and hemangioma simplex in the parietal regions, which are typically associated with potential neural tube defects. However, imaging and histopathological examinations did not reveal any bone defects or heterotopic neural tissue. Both cases showed abnormalities in ectodermal fusion, characterized by a flat epidermis, absence of appendages, and melanocytes in the superficial dermal layer. Additionally, there was macrophage hyperplasia in the dermal area, lacking elastic and normal collagen fibers, and peripheral hair follicles grew horizontally.
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