The Use of Human Dermal Papillae Conditioned Medium (HDPCM) on Aplasia Cutis Congenita in Lower Extremity Due to Intrauterine Varicella Infection

    March 2019 in “ KnE life sciences ”
    Suci Widhiati, Retno Dwi Utami, Dendy Zulfikar, Arie Kusumawardani, endra yustin, Triasari, Kristin Purnama Dewi, Nurrachmat Mulianto, Prasetyadi Mawardi, Indah Julianto
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    TLDR HDPCM treatment healed a baby's congenital skin defect caused by varicella infection.
    The study reported the successful use of Human Dermal Papillae Conditioned Medium (HDPCM) to treat a 4-day-old baby boy with Aplasia Cutis Congenita (ACC) on both knees, caused by intrauterine varicella infection. After 10 days of topical HDPCM treatment, which is rich in growth factors like IGF-I, HGF, VEGF, and TGF-B1, the baby showed significant improvement with complete wound closure, reduced inflammation, and less scarring. This case highlighted the potential of HDPCM in promoting neovascularization, tissue maturation, and faster healing in ACC, a rare congenital skin defect.
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