Possible Protective Effect of Hydroxychloroquine on Delaying the Occurrence of Integument Damage in Lupus: Data from a Multiethnic Cohort

January 2010 in “ Arthritis Care & Research ”

Guillermo J. Pons‐Estel, Graciela S. Alarcón, Luis Alonso González, Jie Zhang, Luis M. Vilá, John D. Reveille, Gerald McGwin

hydroxychloroquine integument damage systemic lupus erythematosus SLE disease activity Plaquenil skin damage lupus

TLDR Hydroxychloroquine may help delay skin damage in lupus patients.

The study investigated the potential protective effect of hydroxychloroquine (HCQ) on delaying integument damage, such as alopecia, in 580 multiethnic patients with systemic lupus erythematosus (SLE) over an average disease duration of 5.9 years. It found that HCQ use was associated with a longer time to integument damage, with 5% of HCQ-takers developing damage at five years compared to 24% of non-takers. Higher disease activity and certain ethnicities (Texan-Hispanic and Caucasian) were also linked to the timing of damage onset. The study suggested HCQ could be beneficial in managing SLE-related integument damage and recommended further research into other environmental factors.

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research Clinical Manifestations of Cutaneous Lupus Erythematosus

148 citations , February 2005 in “Autoimmunity Reviews”

Most people with systemic lupus erythematosus have skin problems, and skin symptoms are often the first sign of the disease.