Progesterone-Induced Stimulation of Mammary Tumorigenesis Is Due to the Progesterone Metabolite, 5α-Dihydroprogesterone (5αP), and Can Be Suppressed by the 5α-Reductase Inhibitor, Finasteride
May 2015
in “
The Journal of Steroid Biochemistry and Molecular Biology
”
TLDR Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.
The study found that the progesterone metabolite 5α-dihydroprogesterone (5αP) is responsible for the stimulation of mammary tumorigenesis induced by progesterone. This effect can be suppressed by the 5α-reductase inhibitor, finasteride. The findings suggest that targeting 5αP may be a potential therapeutic strategy for breast cancer treatment.
