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Progesterone-Induced Stimulation of Mammary Tumorigenesis Is Due to the Progesterone Metabolite, 5α-Dihydroprogesterone (5αP), and Can Be Suppressed by the 5α-Reductase Inhibitor, Finasteride

research Progesterone-Induced Stimulation of Mammary Tumorigenesis Is Due to the Progesterone Metabolite, 5α-Dihydroprogesterone (5αP), and Can Be Suppressed by the 5α-Reductase Inhibitor, Finasteride

21 citations, May 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

research Effect of Finasteride on the Ovulatory Function of Normal Women

4 citations, June 2003 in “Fertility and Sterility”

Finasteride doesn't affect ovulation in normal women.

research Relationships Between Cerebrospinal Fluid GABAergic Neurosteroid Levels and Symptom Severity in Men with PTSD

59 citations, November 2018 in “Psychoneuroendocrinology”

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

research Finasteride Inhibits the Disease-Modifying Activity of Progesterone in the Hippocampus Kindling Model of Epileptogenesis

26 citations, September 2012 in “Epilepsy & Behavior”

Finasteride worsens seizures in epilepsy rats and speeds up epileptogenesis in mice.

research Finasteride Inhibits the Progesterone-Induced Spike-Wave Discharges in a Genetic Model of Absence Epilepsy

23 citations, July 2003 in “Pharmacology, Biochemistry and Behavior”

Finasteride blocks progesterone's effect on absence seizures in rats.

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Community Join

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community I've been afraid to start Finasteride treatment for 5 years, on it for 2 weeks, regret that hadn't started it earlier and here's my story

in Finasteride/Dutasteride 31 upvotes 3 years ago

A 28-year-old male, losing hair since his teens, started taking 0.31 mg finasteride daily for two weeks with no side effects and regrets not starting earlier. He tried various treatments like minoxidil, scalp massages, and vitamins but found finasteride most effective.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 73 upvotes 4 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

in Finasteride/Dutasteride 191 upvotes 2 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community Proof that finasteride messes with neurosteroids

in Research/Science 230 upvotes 5 months ago

Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

community Finasteride affects both 5a reductase and 5b reductase

6 upvotes 5 years ago

Finasteride not only inactivates the 5a reductase enzyme but also affects the 5b reductase enzyme in a dose-dependent manner, which can impact sexual behavior and brain activity. The user experienced significant hair regrowth and side effects on 1mg of finasteride, which diminished after reducing the dose to 0.5mg, leading to no side effects and further hair improvement.

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