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Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

Finasteride doesn't affect ovulation in normal women.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

Finasteride worsens seizures in epilepsy rats and speeds up epileptogenesis in mice.

Finasteride blocks progesterone's effect on absence seizures in rats.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Finasteride may affect fetal brain development and increase arousal, but more research is needed for safety confirmation.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Finasteride may cause long-lasting sexual side effects.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

Stress worsens Tourette symptoms by increasing allopregnanolone levels.

A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

Certain drugs change freshwater snail shells to a "banana" shape.

Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.

Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Finasteride for hair loss can cause long-lasting sexual side effects like low libido and erectile dysfunction.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

Male tissue has more cell death than female tissue after ischemia, and some neurosteroids only protect female cells.

The steroids allopregnanolone and allotetrahydrodeoxycorticosteron worsened absence seizures in rats.

Finasteride given to baby rats reduces dopamine release and increases alcohol consumption in adult males.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.