Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery

September 2018 in “ Medicines ”

Pawan Kumar, Shailendra Singh, Vandana Handa, Himanshu Kathuria

oleic acid nanovesicles minoxidil follicular delivery alopecia areata drug absorption hair follicles OAV gel drug deposition skin slow release Rogaine

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary This study reported that oleic acid-based nanovesicles improve follicular delivery and reduce side effects of minoxidil compared to traditional MXD lotions. Our plain-language summary of this paper — not a Tressless recommendation.

This document is a collection of summaries of a scientific paper titled "Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery" from 2018. The study explores the use of oleic acid nanovesicles (OAVs) as a delivery system for minoxidil to enhance drug absorption into hair follicles for the treatment of alopecia areata. The results showed that the OAV gel had a higher drug deposition in the skin and hair follicles compared to the lotion, and the drug was released slowly over time. The study suggests that OAVs could be a promising delivery system for the treatment of alopecia areata.

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Research cited in this study

25 / 25 results

research Mechanism of Action of Minoxidil in the Treatment of Androgenetic Alopecia Is Likely Mediated by Mitochondrial Adenosine Triphosphate Synthase-Induced Stem Cell Differentiation

6 citations , February 2018 in “PubMed”

This study suggests that minoxidil may promote hair growth in androgenetic alopecia by increasing intracellular calcium, which enhances stem cell differentiation, offering insights for new drug development.

research Formulation and Evaluation of Minoxidil Gel Using Acrylamide/Sodium Acryloyldimethyl Taurate Copolymer for Alopecia Areata

1 citations , January 2018 in “International Journal of Pharmaceutical Sciences and Drug Research”

This study describes the development of a minoxidil gel using the copolymer Sepineo P 600, showing improved spreadability, occlusivity, adhesiveness, and stability compared to minoxidil lotion, without causing skin corrosion, making it a potentially more effective treatment form for alopecia areata.

research Alginate-Based Hydrogel Containing Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex for Topical Alopecia Treatment

19 citations , November 2017 in “Journal of Pharmaceutical Sciences”

This research investigated aqueous alginate-based hydrogels for delivering minoxidil and reported that using hydroxypropyl-β-cyclodextrin (HP-β-CD) with molar substitution 0.65 significantly enhanced minoxidil's solubility and skin permeability without damaging the epidermis, suggesting potential as an alternative to commercial minoxidil solutions.

Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

research Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

19 citations , October 2017 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study found that the MXD/HP-β-CD GEL formulation promoted greater hair growth and improved gene expression related to hair growth in male rats compared to MXD solution or control groups.

research Preparation and In Vivo Evaluation of Lecithin-Based Microparticles for Topical Delivery of Minoxidil

12 citations , August 2017 in “Archives of Pharmacal Research”

In this study, lecithin-based microparticle formulations of minoxidil showed enhanced skin penetration and comparable hair growth effectiveness to commercial products in mice, while minimizing skin irritation often seen with standard minoxidil solutions.

research Solid Effervescent Formulations as a New Approach for Topical Minoxidil Delivery

33 citations , October 2016 in “European Journal of Pharmaceutical Sciences”

This study found that a novel effervescent formulation significantly increased minoxidil sulphate accumulation in hair follicles and skin compared to a standard minoxidil solution.

research Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth

23 citations , January 2016 in “Theranostics”

In this animal study, ultrasound combined with a new microbubble formulation of minoxidil increased hair growth rates and improved follicle characteristics more effectively than minoxidil alone.

research Intradermal and Follicular Delivery of Adapalene Liposomes

27 citations , September 2015 in “Drug development and industrial pharmacy”

This study demonstrated that adapalene encapsulated in liposomes significantly improved drug delivery to hair follicles compared to gel and drug solution, potentially targeting acne treatment more effectively.

Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells

research Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells

17 citations , May 2015 in “Nanomedicine: Nanotechnology, Biology and Medicine”

This study found that lipid nanocarriers called squarticles, conjugated with an antibody, enhanced minoxidil uptake in dermal papilla cells, potentially improving alopecia treatments.

New Ethanol and Propylene Glycol Free Gel Formulations Containing a Minoxidil-Methyl-Beta-Cyclodextrin Complex as Promising Tools for Alopecia Treatment

research New Ethanol and Propylene Glycol Free Gel Formulations Containing a Minoxidil-Methyl-Beta-Cyclodextrin Complex as Promising Tools for Alopecia Treatment

18 citations , March 2014 in “Drug Development and Industrial Pharmacy”

This study evaluated new aqueous gel formulations of minoxidil without irritants and found that the calcium alginate gel showed the best performance in terms of drug release and skin permeation.

research Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells

62 citations , December 2013 in “Aaps Journal”

This research reported that squarticles, nanoparticles made from sebum-derived lipids, enhanced the follicular delivery and skin accumulation of diphencyprone and minoxidil, indicating effective drug deposition with reduced systemic absorption in alopecia treatment.

research Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carrier Gel for Effective Treatment of Alopecia

101 citations , October 2013 in “Journal of The Saudi Pharmaceutical Society”

This study found that the nanostructured lipid carrier gel containing minoxidil showed good consistency and a prolonged drug release in vitro, suggesting potential for treating alopecia.

research Solid Lipid Nanoparticles Suspension Versus Commercial Solutions for Dermal Delivery of Minoxidil

26 citations , June 2011 in “International Journal of Pharmaceutics”

This study found that solid lipid nanoparticles with minoxidil were as effective as commercial solutions for skin penetration and were non-corrosive, indicating potential for hair loss treatment.

research Follicular and Percutaneous Penetration Pathways of Topically Applied Minoxidil Foam

74 citations , June 2010 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study found that hair follicles are a significant and efficient pathway for the absorption of topical minoxidil foam in humans, with faster blood detection when follicles are open.

research Transcutol-Containing Vesicles for Topical Delivery of Minoxidil

51 citations , May 2010 in “Journal of Drug Targeting”

This study found that Transcutol-containing vesicles improved the delivery of minoxidil to deeper skin layers in vitro but did not facilitate its permeation through the skin.

research In Vitro Skin Permeation of Monoolein Nanoparticles Containing Hydroxypropyl β-Cyclodextrin/Minoxidil Complex

39 citations , April 2010 in “International Journal of Pharmaceutics”

This study found that using monoolein cubic phase nanoparticles with an entrapped hydroxypropyl β-cyclodextrin/minoxidil complex increased minoxidil skin permeation, but minoxidil retention in the skin was higher with a traditional solution.

research The Effects of Particle Properties on Nanoparticle Drug Retention and Release in Dynamic Minoxidil Foams

25 citations , January 2010 in “International Journal of Pharmaceutics”

This study found that polymeric nanoparticles retained more minoxidil and facilitated superior drug permeation compared to lipid nanoparticles, although premature drug release affected formulation performance.

research Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil

128 citations , July 2009 in “International Journal of Pharmaceutics”

This study found that penetration enhancer-containing vesicles significantly improved minoxidil delivery to the skin compared to traditional liposomes and penetration enhancer-containing ethanolic solutions, with deformability linked to enhanced deposition.

research Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro

55 citations , June 2009 in “Journal of Pharmaceutical Sciences”

This study found that ethanol-containing formulations significantly increased minoxidil retention in the stratum corneum and appendages initially, while a propylene glycol-rich formulation enhanced deeper skin penetration over time.

research Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery

268 citations , April 2009 in “International Journal of Pharmaceutics”

In this study, niosomal formulations enhanced minoxidil skin accumulation compared to commercial and control solutions, suggesting a potential improvement for topical delivery in hair loss treatment.

research Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles

162 citations , August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study introduces a novel non-invasive method called "differential stripping" to quantify the penetration of topically applied substances into hair follicles.

Positive Lymphocyte Transformation Test in a Patient with Allergic Contact Dermatitis of the Scalp After Short-Term Use of Topical Minoxidil Solution

research Positive Lymphocyte Transformation Test in a Patient with Allergic Contact Dermatitis of the Scalp After Short-Term Use of Topical Minoxidil Solution

38 citations , June 2005 in “Contact Dermatitis”

This case report describes a patient with an allergic sensitization to minoxidil, indicating that such patients should pursue alternative therapies to treat androgenetic alopecia.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

This article reviews the mechanisms by which minoxidil stimulates hair growth and reports no new clinical findings.

research Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment

123 citations , February 2002 in “Journal of The American Academy of Dermatology”

Minoxidil can cause skin allergy; use alternative solvents or treatments if allergic.

research Penetration of Minoxidil from Ethanol/Propylene Glycol Solutions: Effect of Application Volume and Occlusion

33 citations , June 1995 in “Journal of Pharmaceutical Sciences”

This study found that minoxidil penetration through the skin increased with higher ethanol content and occlusion, with the highest penetration observed at 90% ethanol.