Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery

September 2018 in “ Medicines ”

Pawan Kumar, Shailendra Singh, Vandana Handa, Himanshu Kathuria

oleic acid nanovesicles minoxidil follicular delivery alopecia areata drug absorption hair follicles OAV gel drug deposition skin slow release Rogaine

TLDR Oleic acid nanovesicles improve minoxidil absorption in hair follicles for alopecia treatment.

This document is a collection of summaries of a scientific paper titled "Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery" from 2018. The study explores the use of oleic acid nanovesicles (OAVs) as a delivery system for minoxidil to enhance drug absorption into hair follicles for the treatment of alopecia areata. The results showed that the OAV gel had a higher drug deposition in the skin and hair follicles compared to the lotion, and the drug was released slowly over time. The study suggests that OAVs could be a promising delivery system for the treatment of alopecia areata.

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Research cited in this study

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research Formulation and Evaluation of Minoxidil Gel Using Acrylamide/Sodium Acryloyldimethyl Taurate Copolymer for Alopecia Areata

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research Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells

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New Ethanol and Propylene Glycol Free Gel Formulations Containing a Minoxidil-Methyl-Beta-Cyclodextrin Complex as Promising Tools for Alopecia Treatment

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research Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells

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Minoxidil-loaded NLC gel shows potential for effective alopecia treatment.

research Solid Lipid Nanoparticles Suspension Versus Commercial Solutions for Dermal Delivery of Minoxidil

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research Follicular and Percutaneous Penetration Pathways of Topically Applied Minoxidil Foam

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Nanoparticles improve minoxidil skin permeation, but more research needed for effective hair growth.

research The Effects of Particle Properties on Nanoparticle Drug Retention and Release in Dynamic Minoxidil Foams

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Particle properties affect drug retention and release in minoxidil foams, with lipid nanoparticles having higher loading capacity.

research Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil

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PEVs improve minoxidil skin penetration, increasing hair growth.

research Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro

55 citations, June 2009 in “Journal of Pharmaceutical Sciences”

Minoxidil promotes hair growth by penetrating skin, with ethanol-containing formulas working best.

research Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery

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research Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles

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The new "differential stripping" method effectively measures how much substance gets into hair follicles.

Positive Lymphocyte Transformation Test in a Patient with Allergic Contact Dermatitis of the Scalp After Short-Term Use of Topical Minoxidil Solution

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Patient had scalp allergy from minoxidil; test helped identify cause and suggest alternative treatments.

research Minoxidil: Mechanisms of Action on Hair Growth

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Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

research Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment

123 citations, February 2002 in “Journal of The American Academy of Dermatology”

Minoxidil can cause skin allergy; use alternative solvents or treatments if allergic.

research Penetration of Minoxidil from Ethanol/Propylene Glycol Solutions: Effect of Application Volume and Occlusion

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More ethanol increases minoxidil delivery, but too much lowers efficiency.

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research Delivery and Targeting of Nanoparticles into Hair Follicles

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