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Research

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research Drug Repositioning: New Approaches and Future Prospects for Life-Debilitating Diseases and the COVID-19 Pandemic Outbreak

170 citations , September 2020 in “Viruses”

This review highlights that drug repositioning offers a cost-effective alternative to traditional drug discovery, especially for treating orphan and resistant diseases like COVID-19, by repurposing existing drugs such as Hydroxychloroquine and Remdesivir.

research Drug repositioning: current approaches and their implications in the precision medicine era

42 citations , January 2018 in “Expert review of precision medicine and drug development”

This review discusses the integration of drug repurposing with personalized medicine through off-label prescribing and reports no new results, highlighting the potential for systematic exploration using omics technologies.

research Network-Based Drug Repositioning: Approaches, Resources, and Research Directions

39 citations , December 2018 in “Methods in molecular biology”

This review discusses the data resources and computational models used in drug repositioning, highlighting their role in discovering unknown drug mechanisms and reports no new empirical results.

research Drug Repositioning with GraphSAGE and Clustering Constraints Based on Drug and Disease Networks

32 citations , May 2022 in “Frontiers in Pharmacology”

This study proposes an AI-based method, DRGCC, using GraphSAGE and clustering constraints to predict associations between drugs and diseases, demonstrating reliable predictive performance that may aid drug repositioning efforts, including exploring drugs for COVID-19 treatment.

research Drug repositioning using in silico compound profiling

24 citations , December 2009 in “Future Medicinal Chemistry”

This study identified new potential targets and indications for several marketed drugs using in silico profiling, suggesting opportunities for drug repositioning.

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Community Join

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community Why liposomal finasteride and minoxidil may be better than traditional topical solutions.

in Research/Science 2 upvotes 1 year ago

Liposomal formulations of finasteride and minoxidil may enhance drug delivery to the skin and hair follicles more effectively than traditional solutions, potentially improving treatment outcomes. However, more human clinical trials are needed to confirm these benefits.

community Different Topical Dutasteride Formulations

3 upvotes 3 years ago

The conversation discusses the best vehicle for topical dutasteride, comparing Trichosol, Transcutol, and a gel version. It also mentions using Transcutol with ethanol to enhance transdermal delivery of Bimatoprost.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

192 upvotes 4 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community Finasteride success for androgenic alopecia by a 27M physician (NO PICTURES)

4 upvotes 10 years ago

A 27-year-old male physician improved hair density using minoxidil 5% foam and finasteride 1mg every other day, with initial sexual side effects that subsided. He recommends trying finasteride for a year but warns against dutasteride due to potential liver effects.

community if Post Finasteride Syndrome is real. Why is it only the negative effects and not positive have log term effect?

in Finasteride/Dutasteride 63 upvotes 5 months ago

Finasteride is used for hair loss, with mixed reports of no side effects and claims of long-term negative effects known as Post Finasteride Syndrome (PFS). The conversation debates the existence and causes of PFS, with differing opinions on whether it is psychological or real.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Baricitinib

Baricitinib: How did a drug for arthritis end up helping people regrow hair from alopecia areata? Baricitinib helps regrow hair by targeting the autoimmune response in alopecia areata.

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Clinics

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14
Hair Loss Treatments
Dr Joydeep Roy's Skin Clinic, New S.S.Medicos, (near Cachar high school), Malugram/ Drugs Corner, itkhola near Cachar CollegeSilchar, Assam · IN

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