Alginate-Based Hydrogel Containing Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex for Topical Alopecia Treatment

    November 2017 in “ Journal of Pharmaceutical Sciences ”
    Nicola Margiotta, Andreas Bernkop-Schnürch, Valentino Laquintana … Massimo Franco
    Studysummary This research investigated aqueous alginate-based hydrogels for delivering minoxidil and reported that using hydroxypropyl-β-cyclodextrin (HP-β-CD) with molar substitution 0.65 significantly enhanced minoxidil's solubility and skin permeability without damaging the epidermis, suggesting potential as an alternative to commercial minoxidil solutions.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on linkinghub.elsevier.com →
    Discuss this study in the Community →

    Research cited in this study 13

    1. Minoxidil–2-Hydroxypropyl-β-Cyclodextrin Inclusion Complexes: Characterization and In Vivo Evaluation of an Aqueous Solution for Hair Growth in Rats Journal of inclusion phenomena and macrocyclic chemistry · 2017
    2. New Ethanol and Propylene Glycol Free Gel Formulations Containing a Minoxidil-Methyl-Beta-Cyclodextrin Complex as Promising Tools for Alopecia Treatment Drug Development and Industrial Pharmacy · 2014
    3. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    4. In Vitro Skin Permeation of Monoolein Nanoparticles Containing Hydroxypropyl β-Cyclodextrin/Minoxidil Complex International Journal of Pharmaceutics · 2010
    5. Synthesis and Characterization of Inclusion Complex of the Vasodilator Drug Minoxidil with β-Cyclodextrin Journal of Inclusion Phenomena and Macrocyclic Chemistry · 2008
    6. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    7. Minoxidil-Containing Dosage Forms: Skin Retention and After-Rinsing Hair-Growth Promotion Drug Delivery · 2003
    8. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    9. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    10. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    11. Dihydrotestosterone and the Concept of 5-Alpha-Reductase Inhibition in Human Benign Prostatic Hyperplasia European Urology · 2000
    12. Male Pattern Hair Loss: Current Understanding International Journal of Dermatology · 1998
    13. Penetration of Minoxidil from Ethanol/Propylene Glycol Solutions: Effect of Application Volume and Occlusion Journal of Pharmaceutical Sciences · 1995

    Related research 1

    1. Alginate-Based Hydrogel Containing Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex for Topical Alopecia Treatment Journal of Pharmaceutical Sciences · 2017