Recent Studies on the Delivery of Hydrophilic Drugs in Nanoparticulate Systems

    September 2015 in “ Journal of Drug Delivery Science and Technology ”
    Gloria Berlier, Luigi Battaglia, Paola Brusa, Roberta Cavalli, Daniela Chirio, Franco Dosio, Marina Gallarate, Paola Milla, Elena Peira, Flavio Rocco, Simona Sapino, Barbara Stella, Elena Ugazio, Maurizio Ceruti
    Image of study
    TLDR Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.
    The document from April 1, 2016, reviews various strategies for enhancing the delivery of hydrophilic drugs using nanoparticulate systems. It discusses the use of liposomes, lipophilic prodrugs, polymer nanocarriers, and techniques like hydrophobic ion pairing and covalent linkage to improve drug encapsulation. Solid lipid nanoparticles (SLNs) are emphasized as promising due to their biocompatibility and versatility in encapsulating drugs like insulin, doxorubicin, and other anticancer agents with good efficiency. The document also explores the use of chitosan nanoparticles, alginate, and squalenoylation technology, which links a squalenoyl chain to drugs, improving bioavailability and targeting while reducing toxicity. Additionally, it covers the application of mesoporous silica nanoparticles for topical drug delivery and nanobubbles for targeted delivery and gene therapy. The review concludes that these drug delivery systems enhance drug performance by regulating release, protecting drugs from degradation, altering pharmacokinetics, and increasing drug concentration in diseased tissues.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 113 results

      community Dr Kyle Gillett on topical Dutasteride

      in Finasteride/Dutasteride  56 upvotes 2 years ago
      The potential effectiveness of topical dutasteride, as well as other hair loss treatments such as finasteride, RU58841, minoxidil, and various vitamins. Experiences from users who have used these treatments were shared.

      community Minoxidil Sulfate makes everyone a responder

      in Research/Science  255 upvotes 1 month ago
      Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

      community 5 months progress post on topical min and fin

      in Is this regrowth?  27 upvotes 5 months ago
      User shared a 5-month progress update on using topical minoxidil 6% and finasteride 0.05% once daily, with microneedling and vitamins. They experienced initial shedding but no side effects, and increased the treatment to twice daily after month 4.

      community Blood work of DHT levels before and after using Topical Fin

      in Treatment  2 upvotes 6 months ago
      A user shared their hair loss journey, detailing the use of topical Minoxidil and Finasteride, and oral Minoxidil. Blood tests showed a decrease in DHT levels after using topical Finasteride, with no side effects but slight hair loss.

    Similar Research

    5 / 1000+ results