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GlossaryLipophilic Drugs

dissolve in fats and easily cross cell membranes

Lipophilic drugs, also known as fat-soluble drugs, are medications that dissolve in fats, oils, and lipids rather than water. This property allows them to easily cross cell membranes, which are composed of lipid bilayers, facilitating their absorption and distribution within the body. These drugs often have longer half-lives and can accumulate in fatty tissues, potentially leading to prolonged effects or toxicity.

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research Recent Studies on the Delivery of Hydrophilic Drugs in Nanoparticulate Systems

47 citations , September 2015 in “Journal of Drug Delivery Science and Technology”

Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

research Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis

26 citations , October 2020 in “Biomedicines”

Bioengineered skin models help reduce animal testing and advance research in cosmetics and skin disease.

research Advances in Nucleoside Monophosphate Prodrugs as Anti-HCV Agents

52 citations , October 2010 in “Antiviral Therapy”

New treatments for Hepatitis C show promise but need more research to confirm their safety and effectiveness for clinical use.

research Structural and Functional Studies of L-PGDS and SMPDL3A Enzymes in Lipid Signaling Family

October 2019

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

research Impact of Ester Promoieties on Transdermal Delivery of Ketorolac

10 citations , January 2014 in “Journal of Pharmaceutical Sciences”

Balancing lipophilicity and solubility is key for effective and safe ketorolac prodrugs.

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community Jxl069 (pp405 api) week 8 update

in Progress Pictures 196 upvotes 4 months ago

The user shared minimal results from using JXL-069 for hair loss, noting a slight lengthening of vellus hairs and plans to switch to a prodrug variant due to limited effectiveness. They also mentioned using finasteride and minoxidil, which have plateaued in results.

community Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better?

in Finasteride/Dutasteride 24 upvotes 11 months ago

Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.

community Topical Dutasteride & Microneedling Works

in Finasteride/Dutasteride 6 upvotes 1 year ago

Topical dutasteride, especially at higher concentrations, can be effective for hair loss when combined with microneedling to enhance absorption. Users discuss the side effects of finasteride and dutasteride, with some preferring topical treatments to avoid systemic side effects.

community Possible solution: 2.5mg DUT for everyone

in Chat 13 upvotes 8 months ago

A user is experimenting with creating a DIY oral Dutasteride solution using raw powder, MCT oil, and Vitamin E to reduce costs. Others discuss their experiences with similar methods and the challenges of sourcing and testing Dutasteride.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 412 upvotes 8 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

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