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    Did you mean Lipophilic Drugs?
    GlossaryLipophilic Drugs

    dissolve in fats and easily cross cell membranes

    Lipophilic drugs, also known as fat-soluble drugs, are medications that dissolve in fats, oils, and lipids rather than water. This property allows them to easily cross cell membranes, which are composed of lipid bilayers, facilitating their absorption and distribution within the body. These drugs often have longer half-lives and can accumulate in fatty tissues, potentially leading to prolonged effects or toxicity.

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      community Jxl069 (pp405 api) week 8 update

      in Progress Pictures  196 upvotes 2 months ago
      The user shared minimal results from using JXL-069 for hair loss, noting a slight lengthening of vellus hairs and plans to switch to a prodrug variant due to limited effectiveness. They also mentioned using finasteride and minoxidil, which have plateaued in results.

      community Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better?

      in Finasteride/Dutasteride  24 upvotes 9 months ago
      Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.

      community Topical Dutasteride & Microneedling Works

      in Finasteride/Dutasteride  6 upvotes 1 year ago
      Topical dutasteride, especially at higher concentrations, can be effective for hair loss when combined with microneedling to enhance absorption. Users discuss the side effects of finasteride and dutasteride, with some preferring topical treatments to avoid systemic side effects.

      community Possible solution: 2.5mg DUT for everyone

      in Chat  14 upvotes 5 months ago
      A user is experimenting with creating a DIY oral Dutasteride solution using raw powder, MCT oil, and Vitamin E to reduce costs. Others discuss their experiences with similar methods and the challenges of sourcing and testing Dutasteride.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  417 upvotes 6 months ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.
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