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GlossaryLipophilic Drugs

dissolve in fats and easily cross cell membranes

Lipophilic drugs, also known as fat-soluble drugs, are medications that dissolve in fats, oils, and lipids rather than water. This property allows them to easily cross cell membranes, which are composed of lipid bilayers, facilitating their absorption and distribution within the body. These drugs often have longer half-lives and can accumulate in fatty tissues, potentially leading to prolonged effects or toxicity.

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research Recent Studies on the Delivery of Hydrophilic Drugs in Nanoparticulate Systems

47 citations, September 2015 in “Journal of Drug Delivery Science and Technology”

Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

research Advances in Nucleoside Monophosphate Prodrugs as Anti-HCV Agents

52 citations, October 2010 in “Antiviral Therapy”

New treatments for Hepatitis C show promise but need more research to confirm their safety and effectiveness for clinical use.

research Structural and Functional Studies of L-PGDS and SMPDL3A Enzymes in Lipid Signaling Family

October 2019

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

research Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs

8 citations, January 2021 in “Pharmaceutics”

Nanoporous silica entrapped lipid-drug complexes significantly improve the solubility and absorption of drugs that don't dissolve well in water.

research Contribution of the Hair Follicular Pathway to Total Skin Permeation of Topically Applied and Exposed Chemicals

39 citations, November 2016 in “Pharmaceutics”

The hair follicle pathway significantly affects how easily water-loving chemicals pass through the skin.

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community Topical Dutasteride & Microneedling Works

in Finasteride/Dutasteride 6 upvotes 7 months ago

Topical dutasteride, especially at higher concentrations, can be effective for hair loss when combined with microneedling to enhance absorption. Users discuss the side effects of finasteride and dutasteride, with some preferring topical treatments to avoid systemic side effects.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 407 upvotes 3 weeks ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community Soundwaves & Electricity Grows Hair? | Peptide Delivery Model.

in Research/Science 2 upvotes 9 months ago

Iontophoresis and sonophoresis can enhance drug delivery into the scalp. Combining these methods may improve the effectiveness of topical treatments like dutasteride and certain peptides.

community Dr Kyle Gillett on topical Dutasteride

in Finasteride/Dutasteride 56 upvotes 2 years ago

The potential effectiveness of topical dutasteride, as well as other hair loss treatments such as finasteride, RU58841, minoxidil, and various vitamins. Experiences from users who have used these treatments were shared.

community Shedding with topical dutasteride (month 4)

in Progress Pictures 29 upvotes 4 weeks ago

The user shared progress pictures after using topical dutasteride for 4 months, experiencing heavy shedding at month 2, which returned to baseline 1.5 months ago. Previous treatments with topical and oral finasteride and minoxidil were ineffective or caused side effects, and the user is hopeful about the shedding phase indicating potential effectiveness of topical dutasteride.

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