Green Formulation of Spironolactone Loaded Chitosan Coated Nano Lipid Carrier for Treatment of Acne Vulgaris: A Randomized Double-Blind Clinical Trial

    September 2023 in “ Advanced Pharmaceutical Bulletin ”
    Majid Saeedi, Katayoun Morteza‐Semnani, Jafar Âkbari … Seyyed Mobin Rahimnia
    Studysummary In a double-blind clinical trial, this study found that a gel containing chitosan-coated spironolactone nanoparticles effectively reduced acne lesions over 8 weeks without adverse skin effects, suggesting potential for enhanced acne treatment through targeted skin delivery.
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    Research cited in this study 5

    1. Development and Optimization of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability Aaps Pharmscitech · 2016
    2. Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia International Journal of Nanomedicine · 2014
    3. Targeting to the Hair Follicles: Current Status and Potential Journal of dermatological science · 2010
    4. RU 58841-Myristate Prodrug Development for Topical Treatment of Acne and Androgenetic Alopecia PubMed · 2005
    5. The Treatment of Acne: The Role of Combination Therapies Journal of the American Academy of Dermatology · 1995