Green Formulation of Spironolactone Loaded Chitosan Coated Nano Lipid Carrier for Treatment of Acne Vulgaris: A Randomized Double-Blind Clinical Trial

    September 2023 in “ Advanced Pharmaceutical Bulletin ”
    Majid Saeedi, Katayoun Morteza‐Semnani, Jafar Âkbari, Zohreh Hajheydari, Amin Goodarzi, Seyyed Sohrab Rostamkalaei, Seyyed Mohammad Hassan Hashemi, Seyyed Mobin Rahimnia
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    Studysummary In a double-blind clinical trial, this study found that a gel containing chitosan-coated spironolactone nanoparticles effectively reduced acne lesions over 8 weeks without adverse skin effects, suggesting potential for enhanced acne treatment through targeted skin delivery. Our plain-language summary of this paper — not a Tressless recommendation.
    This study developed a chitosan-coated nano lipid carrier (NLC) for delivering spironolactone (SPN) to treat acne vulgaris. By optimizing the Hydrophilic-Lipophilic Balance (HLB) values, the researchers achieved a formulation with a particle diameter of 238.4 nm and an encapsulation efficiency of 79.88%. The chitosan coating enhanced the NLC's properties, leading to sustained release and effective treatment of mild to moderate acne in a double-blind clinical trial. The trial showed significant improvement in healing and lesion reduction after 8 weeks without adverse effects, suggesting that chitosan-coated SPN-NLCs are promising for targeted acne treatment.
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