Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia

    November 2014 in “ International Journal of Nanomedicine ”
    Rehab Nabil Shamma, Mona Hassan Aburahma
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    TLDR Using nanostructured lipid carriers to deliver spironolactone could improve treatment for hair loss.
    The study from 2014 explored the use of nanostructured lipid carriers (NLCs) to deliver spironolactone (SL), an FDA-approved antiandrogenic drug, for the treatment of alopecia. The researchers created SL-loaded NLCs with an entrapment efficiency of 74.90% to 91.20% and a particle size ranging from 215.6 nm to 834.3 nm. The NLCs demonstrated good stability and a uniform size distribution. The optimized NLC formulation released 66% of the drug over 24 hours, which was significantly higher than the 40% released from the drug suspension. The study concluded that the optimized NLCs are a promising method for targeted delivery of SL to hair follicles, potentially enhancing therapeutic efficacy and reducing side effects compared to oral administration. The study involved 8 experimental runs with different SL-NLC formulations.
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      in Treatment  7 upvotes 2 months ago
      Spironolactone is more potent and lowers testosterone and DHT, while dutasteride only impacts DHT. For female hair loss, checking hormones and considering treatments like oral minoxidil, spironolactone, or topical minoxidil is recommended.

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      in Finasteride/Dutasteride  4 upvotes 3 months ago
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      in Progress Pictures  224 upvotes 7 months ago
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      community Spironolactone topically with a try ?!

      in Research/Science  1 upvotes 9 months ago
      A 30-year-old male is considering using dutasteride and fluridil for hair loss maintenance and is curious about the effectiveness of topical spironolactone, as he cannot take finasteride. He is also planning a hair transplant.

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      in Treatment  4 upvotes 1 year ago
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      in Female  3 upvotes 1 year ago
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