Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia

    November 2014 in “ International Journal of Nanomedicine ”
    Rehab Nabil Shamma, Mona Hassan Aburahma
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    TLDR Using nanostructured lipid carriers to deliver spironolactone could improve treatment for hair loss.
    The study from 2014 explored the use of nanostructured lipid carriers (NLCs) to deliver spironolactone (SL), an FDA-approved antiandrogenic drug, for the treatment of alopecia. The researchers created SL-loaded NLCs with an entrapment efficiency of 74.90% to 91.20% and a particle size ranging from 215.6 nm to 834.3 nm. The NLCs demonstrated good stability and a uniform size distribution. The optimized NLC formulation released 66% of the drug over 24 hours, which was significantly higher than the 40% released from the drug suspension. The study concluded that the optimized NLCs are a promising method for targeted delivery of SL to hair follicles, potentially enhancing therapeutic efficacy and reducing side effects compared to oral administration. The study involved 8 experimental runs with different SL-NLC formulations.
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      community Spironolactone and pregnancy planning

      in Female  2 upvotes 1 week ago
      A user with AGA uses topical spironolactone 2% due to side effects from the oral form and is concerned about its use during conception and breastfeeding. They seek alternatives to prevent AGA relapse while planning pregnancy and after childbirth.

      community spironolactone pills to topical

      in Research/Science  4 upvotes 3 weeks ago
      Crushing spironolactone pills and combining them with minoxidil for topical application may be effective for hair loss, with the addition of finasteride suggested. Adding rosemary and peppermint oils can help mask the unpleasant smell.

      community Does the effect of spironolactone on androgenetic alopecia really weaken over time?

      in Female  4 upvotes 2 months ago
      Spironolactone can remain effective for a long time in treating androgenetic alopecia, but it may not completely stop hair loss. Hair loss treatments like spironolactone, finasteride, and dutasteride slow down hair loss rather than cure it, and their effectiveness can vary based on individual response and the aggressiveness of the condition.

      community Spironolactone VS dutasteride for female pattern hair loss

      in Treatment  7 upvotes 8 months ago
      Spironolactone is more potent and lowers testosterone and DHT, while dutasteride only impacts DHT. For female hair loss, checking hormones and considering treatments like oral minoxidil, spironolactone, or topical minoxidil is recommended.

      community Spironolactone, what do you think?

      in Finasteride/Dutasteride  4 upvotes 9 months ago
      A user is considering Spironolactone for hair loss but is advised against it due to its effects on testosterone. Instead, they are recommended to try finasteride at 18 and consider dutasteride if needed.

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