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GlossaryNon-Lesional Control (NLC)

sample from unaffected area used for comparison in studies

Non-Lesional Control (NLC) refers to a sample of tissue or skin that is taken from an area not affected by a disease or condition, used as a baseline or comparison in scientific studies. In the context of hair and alopecia research, NLC samples are often compared to lesional samples (affected areas) to understand the differences and underlying mechanisms of the condition.

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research Novel Natural Lipids Based NLC Containing Finasteride Improved Androgenetic Alopecia Treatment in Rats

October 2024 in “International Journal of Pharmaceutics”

Finasteride in lipid carriers improved hair growth in rats.

research Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carrier Gel for Effective Treatment of Alopecia

101 citations, October 2013 in “Journal of The Saudi Pharmaceutical Society”

Minoxidil-loaded NLC gel shows potential for effective alopecia treatment.

research Applications and Limitations of Lipid Nanoparticles in Dermal and Transdermal Drug Delivery via the Follicular Route

95 citations, July 2015 in “European journal of pharmaceutics and biopharmaceutics”

Lipid nanoparticles can help deliver drugs through hair follicles but struggle to penetrate deeper skin layers.

research Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia

89 citations, November 2014 in “International Journal of Nanomedicine”

Using nanostructured lipid carriers to deliver spironolactone could improve treatment for hair loss.

research Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells

62 citations, December 2013 in “Aaps Journal”

Squarticles effectively deliver hair growth drugs to follicles and dermal papilla cells.

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community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Convinced dad to get into minox 2 months ago and fin 1 month ago

in Is this regrowth? 208 upvotes 5 months ago

A user convinced their dad to start using Minoxidil two months ago and Finasteride one month ago for hair regrowth. The dad is showing significant progress, and there are suggestions to add derma stamping for better results.

community Melatonin a possible tool to help fight AGA hair loss.

in Research/Science 54 upvotes 3 years ago

Topical melatonin may help reduce hair loss and increase hair thickness in people with androgenetic alopecia (AGA), with some studies showing positive results. It can be mixed with minoxidil for application, and its effectiveness might be enhanced when used with micro-needling, but results may vary among individuals.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.