Minoxidil-Loaded Nanostructured Lipid Carriers: Characterization and Rheological Behavior of Topical Formulations

March 2009 in “ Die Pharmazie ”

Ana Catarina Silva, Delfim Santos, Domingos Ferreira, Eliana B. Souto

minoxidil nanostructured lipid carriers NLC stearic acid oleic acid poloxamer 188 Carbopol perfluorocarbon-based hydrogels rheological behavior pseudoplastic behavior Rogaine

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

oleic acid →

Studysummary This study describes the development of nanostructured lipid carriers for minoxidil as a potential alternative to conventional topical solutions, showing promise for use in topical formulations.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Liposomes And Niosomes As Potential Carriers For Dermal Delivery Of Minoxidil

85 citations , January 2007 in “Journal of Drug Targeting”

This study found that liposomal formulations improved minoxidil delivery to skin layers compared to niosomes and a control solution, suggesting enhanced potential for topical hair loss treatment.

research Liposomes and Niosomes as Topical Drug Delivery Systems

205 citations , January 2005 in “Skin pharmacology and physiology”

This review discusses how liposomes and niosomes can enhance drug penetration in topical delivery systems and emphasizes the importance of their specific composition, size, and type, but it reports no new results.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

This article reviews the mechanisms by which minoxidil stimulates hair growth and reports no new clinical findings.

research Follicular Liposomal Delivery Systems

55 citations , January 2002 in “Journal of liposome research”

This research explores developing liposomal formulations to enhance the delivery of difficult-to-absorb agents directly to hair follicles and sebaceous glands, with minoxidil and plasmid DNA as study molecules.

research Penetration of Minoxidil from Ethanol/Propylene Glycol Solutions: Effect of Application Volume and Occlusion

33 citations , June 1995 in “Journal of Pharmaceutical Sciences”

This study found that minoxidil penetration through the skin increased with higher ethanol content and occlusion, with the highest penetration observed at 90% ethanol.

research Erythema Multiforme Following Topical Minoxidil

10 citations , November 1993 in “Indian Journal of Dermatology Venereology and Leprology”

This report observed that a male developed erythema multiforme linked to both topical and oral minoxidil use for androgenetic alopecia, supported by eruption recurrence with reapplication.

research Topical Minoxidil Solution (1% and 5%) in the Treatment of Alopecia Areata

101 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil solution helps hair regrowth in alopecia areata, with 5% being more effective.

research Contact Dermatitis to Minoxidil

34 citations , September 1985 in “Contact Dermatitis”

Minoxidil can cause skin irritation like eczema and rash in some users.

$Treatment of Refractory Hypertension$

research Treatment of Refractory Hypertension

51 citations , April 1982 in “Lancet”

This study found that multiple treatment regimens for refractory hypertension were effective in controlling blood pressure in most patients, with diazoxide being the most effective but least tolerable option.

research Reversal of Baldness in Patient Receiving Minoxidil for Hypertension

95 citations , December 1980 in “The New England Journal of Medicine”

Minoxidil helped bald patient regrow hair.

research Minoxidil in Resistant Hypertension

102 citations , September 1977 in “The Lancet”

Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.

research Minoxidil in Severe Hypertension with Renal Failure

100 citations , March 1973 in “American Journal of Cardiology”

Minoxidil effectively lowers blood pressure without major side effects.