Treatment of Refractory Hypertension
April 1982
in “
Lancet
”
New to Minoxidil? There is a guide in the encyclopedia. Read the guide → 
Studysummary This study found that multiple treatment regimens for refractory hypertension were effective in controlling blood pressure in most patients, with diazoxide being the most effective but least tolerable option. Our plain-language summary of this paper — not a Tressless recommendation.
In a study from 1982 involving 126 patients with hypertension resistant to conventional treatment, various regimens were assessed, including oral diazoxide, minoxidil, captopril, and quadruple therapy. The study found that blood pressure could be controlled in nearly all patients, with no deaths from cerebrovascular disease during treatment. However, 2 patients died from renal failure, 5 required long-term haemodialysis, and ischaemic heart disease caused 10 deaths. Diazoxide was the most effective in controlling blood pressure but was also the most difficult and unpleasant to use. Captopril was well-tolerated but failed in 6 out of 15 patients. The study concluded that while no treatment is perfect, there are now enough alternatives to manage blood pressure in patients with refractory hypertension effectively.
