Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better? 1/13/2025
Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.
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5 / 5 resultscommunity Real world data from Europe shows that DUT is significantly safer than FIN in long term use
Dutasteride is safer than finasteride for long-term use, with fewer sexual side effects. Users experience better hair regrowth and fewer side effects with dutasteride.
community Phase II topical dut study - outperforms oral fin with a minor DHT reduction
Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.
community 6 Months Into Dut Progress Pictures
Switching from finasteride to dutasteride caused significant shedding but minimal side effects. The user plans to continue dutasteride for 12 months despite concerns about hair density.
community DHT is NOT very important for adults, is it?
A user experienced negative side effects, including low libido and lack of motivation, after using finasteride for hair loss and felt better after stopping it. Others shared similar experiences with finasteride and dutasteride, while some reported no side effects, showing varied individual responses.
community Out of curiosity, why are Finasteride pills formulated as small tablets, while Dutasteride pills are much larger soft gel capsules?
Finasteride and Dutasteride are used for hair loss, with Dutasteride often in gel form for better bioavailability. Switching from Finasteride to Dutasteride is common, with some users combining treatments like Minoxidil for improved results.
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