Encapsulation In Cyclodextrins Of Compounds With Activity Against Male Androgenetic Alopecia

The study focused on improving the solubility and skin penetration of finasteride, dutasteride, and minoxidil, which are used to treat male androgenetic alopecia, by encapsulating them in cyclodextrins. These compounds typically have low aqueous solubility, leading to poor cellular membrane penetration and potential scalp irritation when formulated in hydroalcoholic solutions for topical application. Cyclodextrins, natural cyclic sugars, can form inclusion complexes with these drugs, enhancing their solubility and bioavailability without the need for alcohol-based solutions. The research aimed to identify the optimal type of cyclodextrin for each drug to increase aqueous solubility and improve topical application, thereby reducing scalp irritation. The study involved examining the complexation of these drugs with various native and modified cyclodextrins and assessing the effect of temperature on the complexation process. The efficacy of complexation was calculated to determine the solubility enhancement for each drug based on the type of cyclodextrin used.