Been using Dutasteride, Ru58841, Minoxidil, and Ketaconozole for years. Still can't stop shed, recession or loss of density.
    Treatment 9/23/2024

    From the encyclopedia
    Dutasteride →

    5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

    RU58841 →

    Experimental topical anti-androgen sold as a research chemical

    Minoxidil →

    Vasodilator used on the scalp and, at low doses, as a tablet

    At a glance
    In this treatment experience post, the primary subjects mentioned are
    💊 Dutasteride (oral) 2.5mg once daily 2 years
    💧 RU58841 (topical) 100mg once daily 2 years
    💊 Minoxidil (oral) 10mg once daily 2 years
    💧 Ketoconazole (topical) every other day 2 years
    💊 Finasteride (oral) 2 years
    💧 Minoxidil (topical) 2 years
    the tone is 😞 negative with no growth results.

    Other terms

    Despite using dutasteride, RU58841, minoxidil, and ketoconazole for years, the user continues to experience severe hair loss and thinning. They seek advice after multiple dermatologists confirmed androgenetic alopecia (AGA) but offered no effective solutions.
    View this post in the Community →

    Similar Community Posts Join

    5 / 5 results

      community 24M seeking help for aggressive androgenetic alopecia - "nuke" stack?

      in Chat  1 upvotes 1 year ago
      A 24-year-old male with aggressive androgenetic alopecia is using 1mg finasteride daily and considering a treatment stack including 0.5mg dutasteride, 2.5mg oral minoxidil, ketoconazole shampoo, Alpecin caffeine shampoo, and RU58841. He seeks advice on the safety and effectiveness of these treatments and whether any adjustments are needed.

      community Any experience with dutasteride 2.5mg dose? (Or any dose more than 0.5 mg).

       2 upvotes 9 months ago
      A user with aggressive androgenic alopecia is considering increasing their dutasteride dose from 0.5 mg to potentially 2.5 mg, while already using oral minoxidil, Nizoral, RU-58841, and dermapen. They are seeking advice on the effectiveness and side effects of higher dutasteride doses, with suggestions to consult a dermatologist and consider a higher Nizoral concentration.

      community Female 37/F - On Meds, but no progress. Add PRP?

       4 upvotes 3 years ago
      A 37-year-old woman with androgenetic alopecia is using spironolactone, oral and topical minoxidil, and considering PRP therapy due to lack of progress. She is unable to obtain finasteride, dutasteride, or bicalutamide and is exploring other options like Clascoterone and RU58841.

      community 1year Fin -> 1 year DUT + oral Minox; No results :(

      in Finasteride/Dutasteride  41 upvotes 3 months ago
      The user tried finasteride, dutasteride, and oral minoxidil for hair loss with no success and was diagnosed with androgenetic alopecia. They are considering increasing dosages and trying other treatments like RU58841, GHK-CU, and clascoterone, while seeking further medical opinions.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

       63 upvotes 2 years ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

    Related Research

    6 / 6 results

      research Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment

      August 2025 in “Drug Design Development and Therapy”
      This review article examines current drugs for androgenetic alopecia, focusing on their mechanisms and clinical efficacy, noting that while finasteride and minoxidil are commonly approved treatments, new drugs targeting different pathogenic pathways have emerged, offering a broader understanding and reference for AGA treatment options.

      research Antiandrogens and Androgen Inhibitors

      November 2020 in “Elsevier eBooks”
      This source outlines various antiandrogen and androgen inhibitor drugs used to treat cutaneous disorders of hyperandrogenism, detailing their mechanisms, uses, dosages, and side effects, with emphasis on spironolactone, finasteride, dutasteride, and oral contraceptives.

      research Experimental and early investigational drugs for androgenetic alopecia

      11 citations , July 2017 in “Expert Opinion on Investigational Drugs”
      This review discusses current and emerging therapeutic strategies for androgenetic alopecia, noting limited evidence but suggesting areas such as prostaglandin analogs, PRP, and progenitor cell therapies as promising future directions.

      research Hair loss and herbs for treatment

      39 citations , September 2013 in “Journal of Cosmetic Dermatology”
      This review summarizes causes and treatments of androgenetic alopecia with a focus on herbs as potential alternatives, but reports no new results and suggests more research is needed to validate these options.