Enhanced Skin Permeation of 5α-Reductase Inhibitors Entrapped into Surface-Modified Liquid Crystalline Nanoparticles

    August 2014 in “ Archives of Pharmacal Research ”
    Thiagarajan Madheswaran, Rengarajan Baskaran, Pasupathi Sundaramoorthy, Bong Kyu Yoo
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    TLDR Special nanoparticles increased skin absorption of hair loss treatments with fewer side effects.
    In the 2014 study, researchers found that surface-modified liquid crystalline nanoparticles (sm-LCN) with chitosan enhanced the skin permeation of finasteride and dutasteride, which are 5α-reductase inhibitors used to treat androgenetic alopecia. The sm-LCNs showed a larger size and positive zeta potential, which contributed to a 1.7- to 4.2-fold increase in drug permeation through porcine skin compared to unmodified LCNs. The study also observed a controlled and delayed drug release from sm-LCNs and confirmed the non-toxicity of the ingredients at concentrations up to 20 µg/ml. The findings suggest that sm-LCNs could improve the topical application of these drugs, maximizing therapeutic effects while minimizing systemic side effects. The research was supported by the Gachon University research fund of 2014.
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      community Finasteride and “anti-aging” effects

      in Treatment  218 upvotes 6 months ago
      Finasteride may help users look younger by suppressing DHT, affecting skin and hair. Users also emphasize skincare, sunscreen, and lifestyle for maintaining a youthful appearance.

      community My Theory Of Androgenic Alopecia

      in Research/Science  19 upvotes 4 months ago
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      in Finasteride/Dutasteride  64 upvotes 1 year ago
      The conversation discusses whether individuals using hair loss treatments like Dutasteride (Dut) or Finasteride (Fin) should regularly check their hormone levels through bloodwork. Some argue it's important to monitor the effects of these medications on hormone levels, while others believe it's unnecessary if there are no side effects, citing cost and practicality concerns.

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      in Satire  134 upvotes 2 years ago
      The conversation discusses the potential link between hair loss treatment pills, specifically finasteride, and infertility. Users share their experiences and opinions, with some suggesting that finasteride can temporarily lower sperm count, while others argue that other factors like age and lifestyle could also contribute to infertility.

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      in Female  62 upvotes 1 year ago
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      community A hill on which I will die: The DHT itch absolutely exists

      in Research/Science  210 upvotes 1 year ago
      The DHT itch is linked to hair loss and persists despite finasteride use; switching to dutasteride helped alleviate the itch and promoted regrowth. Some users suggest seborrheic dermatitis as a cause and recommend treatments like medicated shampoos, vitamin D, and minoxidil.

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