Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants

    September 2013 in “ Aaps Pharmscitech ”
    Thiagarajan Madheswaran, Rengarajan Baskaran, Chul Soon Yong, Bong Kyu Yoo
    Studysummary This study found that liquid crystalline nanoparticles formulated with Cremophor surfactants significantly enhanced skin permeation of finasteride compared to lower surfactant concentrations.
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    Research cited in this study 8

    1. Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery Aaps Pharmscitech · 2012
    2. Effects of 5-Alpha Reductase Inhibitors on Erectile Function, Sexual Desire, and Ejaculation Expert Opinion on Drug Safety · 2012
    3. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
    4. Guidelines for the Management of Androgenetic Alopecia (2010) Journal of Dermatology · 2011
    5. Oral Finasteride Improved the Quality of Life of Androgenetic Alopecia Patients Journal of Dermatology · 2010
    6. Enhancement of Percutaneous Absorption of Finasteride by Cosolvents, Cosurfactant, and Surfactants Pharmaceutical Development and Technology · 2009
    7. Androgenetic Alopecia in Males: A Histopathological and Ultrastructural Study Journal of Cosmetic Dermatology · 2009
    8. Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes International Journal of Pharmaceutics · 2006