Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants
September 2013
in “
Aaps Pharmscitech
”
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Studysummary This study found that liquid crystalline nanoparticles formulated with Cremophor surfactants significantly enhanced skin permeation of finasteride compared to lower surfactant concentrations.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study investigated the use of glyceryl monooleate-based liquid crystalline nanoparticles (LCN) stabilized by Cremophor surfactants for enhanced topical delivery of finasteride (FNS) for the treatment of hair loss. The study found that the use of Cremophor RH 40 and Cremophor EL surfactants improved the skin permeation and retention of FNS in porcine skin. The study suggests that the use of LCN with appropriate surfactants can improve the topical delivery of FNS for the treatment of hair loss.
