Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants

September 2013 in “ Aaps Pharmscitech ”

Thiagarajan Madheswaran, Rengarajan Baskaran, Chul Soon Yong, Bong Kyu Yoo

finasteride glyceryl monooleate liquid crystalline nanoparticles Cremophor surfactants Cremophor RH 40 Cremophor EL skin permeation skin retention porcine skin Propecia LCN

Studysummary This study found that liquid crystalline nanoparticles formulated with Cremophor surfactants significantly enhanced skin permeation of finasteride compared to lower surfactant concentrations.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery

58 citations , December 2012 in “Aaps Pharmscitech”

This study suggests that finasteride-loaded liquid crystalline nanoparticles could be a viable alternative to oral administration for treating androgenetic alopecia due to their controlled release and skin permeation properties.

research Effects of 5-Alpha Reductase Inhibitors on Erectile Function, Sexual Desire, and Ejaculation

71 citations , November 2012 in “Expert Opinion on Drug Safety”

This article reviews the reported sexual and psychological side effects of 5-alpha reductase inhibitors for benign prostatic hyperplasia, emphasizing the need for further clinical studies.

research Persistent Sexual Side Effects of Finasteride: Could They Be Permanent?

112 citations , July 2012 in “The Journal of Sexual Medicine”

In this study, 96% of men with persistent sexual side effects from finasteride reported continued dysfunction after discontinuation, suggesting these effects may endure long-term.

research Guidelines for the Management of Androgenetic Alopecia (2010)

38 citations , December 2011 in “Journal of Dermatology”

This article reviews current guidelines for managing androgenetic alopecia and highlights the need for guidelines tailored to Japan; it reports no new clinical results.

research Oral Finasteride Improved the Quality of Life of Androgenetic Alopecia Patients

23 citations , December 2010 in “Journal of Dermatology”

In this study, oral finasteride improved the quality of life for male patients with androgenetic alopecia, but it did not significantly reduce anxiety or correlate with reported anxiety levels.

research Enhancement of Percutaneous Absorption of Finasteride by Cosolvents, Cosurfactant, and Surfactants

24 citations , November 2009 in “Pharmaceutical Development and Technology”

This study found that Transcutol P significantly enhanced the skin penetration of Finasteride in vitro, while cationic and anionic surfactants did not show such effects.

research Androgenetic Alopecia in Males: A Histopathological and Ultrastructural Study

42 citations , June 2009 in “Journal of Cosmetic Dermatology”

In this study, researchers observed that follicular microinflammation significantly contributes to the early stages of male androgenetic alopecia, potentially leading to perifollicular fibrosis and follicle destruction as the condition progresses.

research Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes

127 citations , June 2006 in “International Journal of Pharmaceutics”

This research found that liquid-state liposomes and niosomes may enhance finasteride delivery to pilosebaceous units in hamsters more effectively than gel-state vesicles or hydroalcoholic solution.