Enhancement of Percutaneous Absorption of Finasteride by Cosolvents, Cosurfactant, and Surfactants

November 2009 in “ Pharmaceutical Development and Technology ”

Yousef Javadzadeh, Javad Shokri, Somayeh Hallaj-Nezhadi, Hamed Hamishehkar, Ali Nokhodchi

finasteride percutaneous absorption penetration enhancers Transcutol P CTAB SLS skin permeation Propecia skin absorption cetyltrimethylammonium bromide sodium lauryl sulfate

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Studysummary This study found that Transcutol P significantly enhanced the skin penetration of Finasteride in vitro, while cationic and anionic surfactants did not show such effects.

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In this study, finasteride, 1 mg daily, significantly increased hair weight more than hair count in men with androgenetic alopecia, indicating additional factors like hair growth rate and thickness may contribute to its effectiveness.

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