In Vitro and In Vivo Skin Distribution of 5α-Reductase Inhibitors Loaded Into Liquid Crystalline Nanoparticles

    June 2017 in “ Journal of Pharmaceutical Sciences ”
    Thiagarajan Madheswaran, Rengarajan Baskaran, Bong Kyu Yoo, Prashant Kesharwani
    Studysummary This study found that coating liquid crystalline nanoparticles with chitosan significantly enhanced the skin permeation of 5α-reductase inhibitors, suggesting a promising strategy for improving topical delivery in androgenetic alopecia treatment.
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    Research cited in this study 13

    1. Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia International Journal of Clinical Pharmacology and Therapeutics · 2015
    2. Emerging Treatments in Alopecia Expert Opinion on Emerging Drugs · 2014
    3. Enhanced Skin Permeation of 5α-Reductase Inhibitors Entrapped into Surface-Modified Liquid Crystalline Nanoparticles Archives of Pharmacal Research · 2014
    4. Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat Journal of Pharmaceutical Sciences · 2014
    5. Chitosan-Decorated Polystyrene-b-Poly(Acrylic Acid) Polymersomes as Novel Carriers for Topical Delivery of Finasteride European Journal of Pharmaceutical Sciences · 2013
    6. Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery Aaps Pharmscitech · 2012
    7. Combination Therapy With Finasteride and Low-Dose Dutasteride in the Treatment of Androgenetic Alopecia Australasian Journal of Dermatology · 2012
    8. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    9. Types of Hair Loss and Treatment Options, Including the Novel Low-Level Light Therapy and Its Proposed Mechanism Southern Medical Journal · 2010
    10. Comparing the Therapeutic Effects of Finasteride Gel and Tablet in Treatment of Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2009
    11. In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers Aaps Pharmscitech · 2008
    12. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    13. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002