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    Novel Iron Oxide Nanocarriers Loading Finasteride or Dutasteride: Enhanced Skin Penetration for Topical Treatment of Alopecia

    Luana Alves Freitas Afiune, Camila Y. Ushirobira, Débora Nice Ferrari Barbosa … María José Soler
    Studysummary This study found that finasteride- and dutasteride-loaded iron oxide nanoparticles improved drug penetration in the skin, suggesting they may be promising for topical alopecia therapies.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 23

    1. Dutasteride Nanocapsules for Hair Follicle Targeting: Effect of Chitosan-Coating and Physical Stimulus International Journal of Biological Macromolecules · 2020
    2. Effect of Physical Stimuli on Hair Follicle Deposition of Clobetasol-Loaded Lipid Nanocarriers Scientific Reports · 2020
    3. The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis Clinical Interventions in Aging · 2019
    4. Efficacy of Off-Label Topical Treatments for the Management of Androgenetic Alopecia: A Review Clinical Drug Investigation · 2019
    5. Prospective Randomized Study of Sexual Function in Men Taking Dutasteride for the Treatment of Androgenetic Alopecia Journal of Dermatology · 2018
    6. Estimation of Zinc and Iron Levels in the Serum and Hair of Women with Androgenetic Alopecia: Case-Control Study Indian Journal of Dermatology · 2018
    7. In Vitro and In Vivo Skin Distribution of 5α-Reductase Inhibitors Loaded Into Liquid Crystalline Nanoparticles Journal of Pharmaceutical Sciences · 2017
    8. Preparation and Characterization of Dutasteride-Loaded Nanostructured Lipid Carriers Coated with Stearic Acid-Chitosan Oligomer for Topical Delivery European Journal of Pharmaceutics and Biopharmaceutics · 2017
    9. Solid Effervescent Formulations as a New Approach for Topical Minoxidil Delivery European Journal of Pharmaceutical Sciences · 2016
    10. Minoxidil Topical Treatment May Be More Efficient If Applied on Damp Scalp Compared to Dry Scalp Dermatologic Therapy · 2016
    11. Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles International Journal of Biological Macromolecules · 2015
    12. Enhanced Skin Permeation of 5α-Reductase Inhibitors Entrapped into Surface-Modified Liquid Crystalline Nanoparticles Archives of Pharmacal Research · 2014
    13. Chitosan-Decorated Polystyrene-b-Poly(Acrylic Acid) Polymersomes as Novel Carriers for Topical Delivery of Finasteride European Journal of Pharmaceutical Sciences · 2013
    14. Penetration Profile and Human Cadaver Skin Distribution of Finasteride from Vesicular Nanocarriers Drug Delivery · 2013
    15. Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants Aaps Pharmscitech · 2013
    16. Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery Aaps Pharmscitech · 2012
    17. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    18. Effect of Charge Carrier Lipid on Skin Penetration, Retention, and Hair Growth of Topically Applied Finasteride-Containing Liposomes Biomolecules & Therapeutics · 2011
    19. Iron Deficiency and Diffuse Nonscarring Scalp Alopecia in Women: More Pieces to the Puzzle Journal of The American Academy of Dermatology · 2010
    20. In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers Aaps Pharmscitech · 2008
    21. The Influence of Selected Steroid Hormones on the Physicochemical Behavior of DPPC Liposomes Chemistry and Physics of Lipids · 2007
    22. Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes International Journal of Pharmaceutics · 2006
    23. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004

    Related research 4

    1. Novel Iron Oxide Nanocarriers Loading Finasteride or Dutasteride: Enhanced Skin Penetration for Topical Treatment of Alopecia International Journal of Pharmaceutics · 2020
    2. Mesotherapy with Dutasteride and Minoxidil in the Treatment of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2018
    3. What Do We Know About 5-Alpha Reductase Inhibitors? Surgical and Cosmetic Dermatology · 2018
    4. The Preventive and Therapeutic Efficacy of Finasteride and Dutasteride in TRAMP Mice The FASEB Journal · 2013