Novel Iron Oxide Nanocarriers Loading Finasteride or Dutasteride: Enhanced Skin Penetration for Topical Treatment of Alopecia

    July 2020 in “ International Journal of Pharmaceutics ”
    Luana Alves Freitas Afiune, Camila Y. Ushirobira, Débora Nice Ferrari Barbosa, Paulo Vitor Dutra de Souza, Maria Inês Gonçalves Leles, Angel Concheiro, Tais Gratieri, María José Soler
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    TLDR Iron oxide nanoparticles improve skin penetration and drug release for hair loss treatment.
    Iron oxide nanoparticles loaded with finasteride or dutasteride were developed for the topical treatment of alopecia. The nanocarriers showed higher skin penetration and drug release compared to control solutions, with DUT-ION being more effective than FIN-ION in increasing drug penetration. The nanocarriers also had a desirable visual characteristic that could help disguise hair follicle areas. The study suggests that the nanoformulations are highly promising for alopecia therapies.
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