Novel Iron Oxide Nanocarriers Loading Finasteride or Dutasteride: Enhanced Skin Penetration for Topical Treatment of Alopecia

September 2020 in “ International Journal of Pharmaceutics ”

Luana Alves Freitas Afiune, Camila Y. Ushirobira, Débora Nice Ferrari Barbosa, Paulo Vitor Dutra de Souza, Maria Inês Gonçalves Leles, Angel Concheiro, Tais Gratieri, María José Soler

iron oxide nanoparticles finasteride dutasteride topical treatment alopecia skin penetration drug release nanocarriers DUT-ION FIN-ION Propecia Avodart

TLDR Iron oxide nanoparticles improve skin penetration and drug release for hair loss treatment.

Iron oxide nanoparticles loaded with finasteride or dutasteride were developed for the topical treatment of alopecia. The nanocarriers showed higher skin penetration and drug release compared to control solutions, with DUT-ION being more effective than FIN-ION in increasing drug penetration. The nanocarriers also had a desirable visual characteristic that could help disguise hair follicle areas. The study suggests that the nanoformulations are highly promising for alopecia therapies.

View this study on sciencedirect.com →

Discuss this study in the Community →

Cited in this study

21 / 21 results

research Dutasteride Nanocapsules for Hair Follicle Targeting: Effect of Chitosan-Coating and Physical Stimulus

26 citations , May 2020 in “International Journal of Biological Macromolecules”

Chitosan-coated dutasteride nanocapsules improve hair treatment, and physical stimulation boosts effectiveness.

research Efficacy of Off-Label Topical Treatments for the Management of Androgenetic Alopecia: A Review

5 citations , March 2019 in “Clinical Drug Investigation”

Some off-label treatments increase hair density, but long-term safety unknown.

research The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis

38 citations , February 2019 in “Clinical Interventions in Aging”

Dutasteride more effectively treats hair loss than finasteride, but may increase risk of altered libido.

research Estimation of Zinc and Iron Levels in the Serum and Hair of Women with Androgenetic Alopecia: Case-Control Study

15 citations , September 2018 in “Indian Journal of Dermatology”

research Prospective Randomized Study of Sexual Function in Men Taking Dutasteride for the Treatment of Androgenetic Alopecia

11 citations , April 2018 in “Journal of Dermatology”

Dutasteride safely treats hair loss without harming sexual function.

research In Vitro and In Vivo Skin Distribution of 5α-Reductase Inhibitors Loaded Into Liquid Crystalline Nanoparticles

32 citations , November 2017 in “Journal of Pharmaceutical Sciences”

Chitosan-coated nanoparticles improve skin delivery of hair loss treatments with fewer side effects.

research Preparation and Characterization of Dutasteride-Loaded Nanostructured Lipid Carriers Coated with Stearic Acid-Chitosan Oligomer for Topical Delivery

47 citations , August 2017 in “European Journal of Pharmaceutics and Biopharmaceutics”

The new dutasteride formula can be applied to the skin, may promote hair growth, and has fewer side effects.

research Solid Effervescent Formulations as a New Approach for Topical Minoxidil Delivery

33 citations , January 2017 in “European Journal of Pharmaceutical Sciences”

Effervescent formulations may improve minoxidil delivery, increasing effectiveness and reducing applications needed.

research Minoxidil Topical Treatment May Be More Efficient If Applied on Damp Scalp Compared to Dry Scalp

13 citations , June 2016 in “Dermatologic Therapy”

Minoxidil works better when applied on a damp scalp than a dry one.

research Penetration Profile and Human Cadaver Skin Distribution of Finasteride from Vesicular Nanocarriers

9 citations , November 2015 in “Drug Delivery”

Ethosomal carriers effectively deliver hair loss drug into skin.

research Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles

77 citations , April 2015 in “International Journal of Biological Macromolecules”

Chitosan nanoparticles improve minoxidil delivery to hair follicles for better alopecia treatment.

research Enhanced Skin Permeation of 5α-Reductase Inhibitors Entrapped into Surface-Modified Liquid Crystalline Nanoparticles

16 citations , August 2014 in “Archives of Pharmacal Research”

Special nanoparticles increased skin absorption of hair loss treatments with fewer side effects.

research Chitosan-Decorated Polystyrene-b-Poly(Acrylic Acid) Polymersomes as Novel Carriers for Topical Delivery of Finasteride

52 citations , February 2014 in “European Journal of Pharmaceutical Sciences”

Chitosan-decorated polymersomes improve finasteride delivery for hair loss treatment.

research Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants

47 citations , February 2014 in “Aaps Pharmscitech”

Improved hair loss treatment using special particles and surfactants.

research Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery

58 citations , March 2013 in “Aaps Pharmscitech”

LCN may improve finasteride delivery for hair loss treatment.

research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations , January 2012 in “Advances in Urology”

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

research Effect of Charge Carrier Lipid on Skin Penetration, Retention, and Hair Growth of Topically Applied Finasteride-Containing Liposomes

11 citations , April 2011 in “Biomolecules & Therapeutics”

research Iron Deficiency and Diffuse Nonscarring Scalp Alopecia in Women: More Pieces to the Puzzle

30 citations , December 2010 in “Journal of The American Academy of Dermatology”

The conclusion suggests a possible link between iron levels and hair health in women, recommending further research on iron supplementation for hair loss.

research In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers

84 citations , July 2008 in “Aaps Pharmscitech”

Ethosomes improve finasteride delivery through skin for hair loss treatment.

research Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes

127 citations , October 2006 in “International Journal of Pharmaceutics”

Liposomes and niosomes improve finasteride delivery for hair loss treatment.

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations , May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

3 / 3 results

research Novel Iron Oxide Nanocarriers Loading Finasteride or Dutasteride: Enhanced Skin Penetration for Topical Treatment of Alopecia

12 citations , September 2020 in “International Journal of Pharmaceutics”

Iron oxide nanoparticles improve skin penetration and drug release for hair loss treatment.

research Mesotherapy with Dutasteride and Minoxidil in the Treatment of Androgenetic Alopecia

1 citations , September 2018 in “Journal of The American Academy of Dermatology”

Dutasteride and minoxidil mesotherapy effectively treats hair loss with minimal side effects.

research What Do We Know About 5-Alpha Reductase Inhibitors?

January 2018 in “Surgical and Cosmetic Dermatology”

5-alpha reductase inhibitors like finasteride and dutasteride are effective for treating enlarged prostate and male pattern hair loss.