Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular Targeting in Androgenic Alopecia Topical Treatment

    November 2024 in “ Pharmaceutics ”
    Jayanaraian F. Martins Andrade, Breno N. Matos, Rafael V. Rocho … Taís Gratieri
    Studysummary This study found that dutasteride-loaded transfersomes, compared to traditional liposomes, better target hair follicles by releasing the drug in a more controlled manner, as shown in vitro with enhanced follicular targeting (Tf = 0.32 versus 0.15, p < 0.005) using porcine ear skin.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 20

    1. The Influence of Sebaceous Content on the Performance of Nanosystems Designed for the Treatment of Follicular Diseases Journal of Drug Delivery Science and Technology · 2020
    2. Dutasteride Nanocapsules for Hair Follicle Targeting: Effect of Chitosan-Coating and Physical Stimulus International Journal of Biological Macromolecules · 2020
    3. Transdermal Delivery of Minoxidil Using HA-PLGA Nanoparticles for the Treatment of Alopecia Biomaterials Research · 2019
    4. Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Upregulating Follicular Sulfotransferase Enzymes Dermatologic Therapy · 2019
    5. Hair Loss: Common Causes and Treatment PubMed · 2017
    6. Androgenetic Alopecia: A Review Endocrine · 2017
    7. Solid Effervescent Formulations as a New Approach for Topical Minoxidil Delivery European Journal of Pharmaceutical Sciences · 2016
    8. Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study Indian Journal of Dermatology, Venereology and Leprology · 2016
    9. Adverse Effects and Safety of 5-Alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review PubMed · 2016
    10. Minoxidil Topical Treatment May Be More Efficient If Applied on Damp Scalp Compared to Dry Scalp Dermatologic Therapy · 2016
    11. Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carriers Aaps Pharmscitech · 2016
    12. A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2014
    13. Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery Aaps Pharmscitech · 2012
    14. Development and Characterization of Dutasteride-Bearing Liposomal Systems for Topical Use Current Drug Discovery Technologies · 2011
    15. Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study Journal of The American Academy of Dermatology · 2010
    16. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    17. Androgens and Hair Loss: An In-Depth Analysis of Androgenetic Alopecia Current Opinion in Endocrinology, Diabetes and Obesity · 2009
    18. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    19. Effective Treatment of Female Androgenic Alopecia with Dutasteride PubMed · 2005
    20. Treatment of Hair Loss The New England Journal of Medicine · 1999

    Related research 1

    1. Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child International journal of research in dermatology · 2019