Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular Targeting in Androgenic Alopecia Topical Treatment

November 2024 in “ Pharmaceutics ”

Jayanaraian F. Martins Andrade, Breno N. Matos, Rafael V. Rocho, Geisa N. Barbalho, Marcílio Cunha‐Filho, Guilherme M. Gelfuso, Taís Gratieri

dutasteride liposomes transfersomes androgenic alopecia hair follicles drug delivery porcine skin Avodart

Studysummary This study found that dutasteride-loaded transfersomes, compared to traditional liposomes, better target hair follicles by releasing the drug in a more controlled manner, as shown in vitro with enhanced follicular targeting (Tf = 0.32 versus 0.15, p < 0.005) using porcine ear skin.

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