Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular Targeting in Androgenic Alopecia Topical Treatment

November 2024 in “ Pharmaceutics ”

Jayanaraian F. Martins Andrade, Breno N. Matos, Rafael V. Rocho, Geisa N. Barbalho, Marcílio Cunha‐Filho, Guilherme M. Gelfuso, Taís Gratieri

dutasteride liposomes transfersomes androgenic alopecia hair follicles drug delivery porcine skin Avodart

TLDR Transfersomes are better than liposomes for targeting hair follicles in alopecia treatment.

The study explores the use of dutasteride-loaded liposomes and transfersomes for treating androgenic alopecia, focusing on enhancing drug delivery to hair follicles. Transfersomes, due to their flexible structure, demonstrated superior follicular targeting (Tf = 0.32) compared to stiffer liposomes (Tf = 0.15) in in vitro tests on porcine skin. This suggests that transfersomes offer better initial control over drug release, making them a promising option for topical treatment. However, over 24 hours, drug distribution equilibrated across skin layers, indicating a need for further optimization to maintain targeting efficacy. The study underscores the potential of transfersomes for improved follicular targeting in alopecia treatment, though additional safety studies are required.

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