Transdermal Delivery of Minoxidil Using HA-PLGA Nanoparticles for the Treatment of Alopecia

October 2019 in “ Biomaterials Research ”

Woo Kyoung Jeong, Sodam Kim, Soo Young Lee, Hyeseon Lee, Dong Soo Han, Seung Hwan Yang, Ki-Hyun Kim

transdermal delivery Minoxidil alopecia Hyaluronate Poly(Lactide-co-Glycolide) nanoparticles HA-PLGA cell viability cellular uptake skin permeation hair follicle cells Rogaine

TLDR Minoxidil in HA-PLGA nanoparticles effectively treats alopecia through skin delivery.

The study aimed to develop a transdermal drug delivery platform for the treatment of alopecia using Minoxidil encapsulated Hyaluronate - Poly(Lactide-co-Glycolide) nanoparticles (HA-PLGA/MXD NPs). The study successfully prepared HA-PLGA/MXD NPs and confirmed their feasibility for treatment of various diseases on skin. The NPs were found to be sufficiently delivered to cells without any significant cytotoxicity by cell viability, cellular uptake and skin permeation test. The study suggests that HA-PLGA NPs as a transdermal delivery carrier to hair follicle cells can be exploited to develop an efficient and effective platform of transdermal drug delivery for the treatment of various diseases.

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